5768-13-8

Basic information

• Product Name: 1-phenylpiperidine-2,6-dione
• Synonyms: 1-Phenylpiperidine-2,6-dione; 2,6-piperidinedione, 1-phenyl-; N-Phenylglutarimide
• CAS NO: 5768-13-8
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.2105
• Mol File: 5768-13-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 407.2°C at 760 mmHg
• Flash Point: 202.7°C
• Density: 1.223g/cm³
• Vapor Pressure: 7.69E-07mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 1-phenylpiperidine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylpiperidine-2,6-dione(5768-13-8)
• EPA Substance Registry System: 1-phenylpiperidine-2,6-dione(5768-13-8)

Safety Data

• Hazardous Substances Data: 5768-13-8(Hazardous Substances Data)

Usage

Physical form

White to off-white crystalline powder

Solubility

Sparingly soluble in water

Uses

Intermediate in the synthesis of pharmaceuticals and other organic compounds; potential use in the synthesis of novel drugs and materials

Unique feature

Unique chemical structure

Research interest

Potential biological and pharmacological activities

Upstream product

• 110-94-1 1,5-pentanedioic acid 
• 62-53-3 aniline 
• 62970-74-5 1-(Phenylamino)-2,6-piperidindion 
• 5414-99-3 4-(phenylcarbamoyl)butyric acid 
• 6833-02-9 N,N'-diphenyl-glutaramide 
• 140192-42-3 C₁₂H₁₃N₃O₂ 
• 2873-74-7 gloutaric dichloride 
• 2325-27-1 N-phenyltriphenyliminophosphorane 
• 1121-89-7 piperidine-2,6-dione 
• 98-80-6 phenylboronic acid 
• 108-55-4 glutaric anhydride, 
• 140192-40-1 N-cyanoglutarimide 
• 622-37-7 Phenyl azide 
• 71-43-2 benzene 

Downstream Products

• 4096-20-2 N-phenyl piperidine 
• 4789-09-7 1-phenylpiperidin-2-one 
• 56416-06-9 Pentanedioic acid hydroxyamide phenylamide 
• 128648-30-6 N-phenyl-6-methylsulfonyl-5-oxo-hexanamide 
• 79261-36-2 2-Chloro-6-oxo-1-phenyl-1,4,5,6-tetrahydro-pyridine-3-carbaldehyde 
• 81305-73-9 2,6-Dichlor-3,5-diformyl-1,4-dihydro-1-phenyl-pyridin 
• 112167-47-2 4-(2,6-Dioxo-piperidin-1-yl)-benzenesulfonyl chloride 
• 1027716-74-0 phosphoric acid 6-oxo-1-phenyl-1,4,5,6-tetrahydro-pyridin-2-yl ester diphenyl ester 
• 91247-37-9 δ-Hydroxy-valeranilid 
• 933803-06-6 6-benzyl-1-phenyl-3,4-dihydro-1H-pyridin-2-one 
• 933803-09-9 6-benzyl-1-phenyl-piperidin-2-one 
• 1027035-96-6 3-benzenesulfinyl-1,6-diphenyl-piperidin-2-one 
• 108979-48-2 1,6-diphenyl-5,6-dihydro-1H-pyridin-2-one 
• 49828-17-3 1,6-diphenyl-3,4-dihydro-1H-pyridin-2-one 

Relevant articles and documents

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Synthesis of some biologically active 2,6-dichloro-1-(N-substituted phenyl)-1,4-dihydropyridine-3,5-Dicarbaldehydes using vilsmeier-haack reaction and their applications

Various 2,6-dichloro-1-(N-substituted phenyl)-1,4-dihydropyridine-3,5- dicarbaldehydes were synthesized in two steps using moderate conditions and 3,5-diformyl groups were transformed into different functionalities. The synthesized compounds were screened

Chemoselective hydrogenation of imides catalyzed by Cp*Ru(PN) complexes and its application to the asymmetric synthesis of paroxetine

This work represents the first catalytic hydrogenation of imides into amides and primary alcohols, in which the unique chemoselectivity is originated from the bifunctional nature of ruthenium-NH moiety in the catalyst. Copyright