57683-62-2

Basic information

• Product Name: 5,6-dehydronorketamine
• Synonyms: 5,6-dehydronorketamine;Dehydro Norketamine;6-AMino-6-(2-chlorophenyl)-2-cyclohexen-1-one;6-amino-6-(2-chlorophenyl)cyclohex-2-en-1-one
• CAS NO: 57683-62-2
• Molecular Formula: C₁₂H₁₂ClNO
• Molecular Weight: 221.686
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 57683-62-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 121-123°C
• Boiling Point: 369.3°Cat760mmHg
• Flash Point: 177.1°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: -20?C Freezer
• PKA: 5.90±0.20(Predicted)
• CAS DataBase Reference: 5,6-dehydronorketamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dehydronorketamine(57683-62-2)
• EPA Substance Registry System: 5,6-dehydronorketamine(57683-62-2)

Safety Data

• Hazardous Substances Data: 57683-62-2(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

InChI:InChI=1/C12H12ClNO/c13-10-6-2-1-5-9(10)12(14)8-4-3-7-11(12)15/h1-3,5-7H,4,8,14H2

Upstream product

• 6740-88-1 ketamine 
• 35211-10-0 norketamine 
• 79499-61-9 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone 

Relevant articles and documents

HYDROXYNORKETAMINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS

Chemical entities of Formula (I): Including enantiomers thereof, wherein R1 has any of the values described herein, and compositions comprising such chemical entities; their preparation; and their use in various methods, including the treatment of depression, pain, cognitive disorders, neurodegenerative disorders, and other neurological and peripheral disorders.

Ketamine metabolism: Identification and synthesis of a deaminated product

During attempts to synthesize 2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone (6), a ketamine metabolite, an unexpected product, 3-(2-chlorophenyl)-2-hydroxy-2-cyclohexenone (4) was obtained as the major product. This compound apparently was formed by rearrangement and deamination of 6 during the isolation and purification procedures. This same compound was found in plasma and urine extracts obtained from mice and rats that had been treated with either ketamine or norketamine. It is suggested that 3-(2-chlorophenyl)-2-hydroxy-2-cyclohexenone (4), isolated from these biological samples, probably arose from decomposition of the 6-hydroxylated metabolite of ketamine or norketamine and is itself not a true metabolite.