5769-35-7 Usage
Description
1,4-Ditosyl-1,4-diazepane is a chemical compound that is a derivative of Fasudil (F150023). It is characterized by its unique molecular structure, which allows it to interact with specific biological targets and exhibit various pharmacological properties.
Uses
Used in Pharmaceutical Industry:
1,4-Ditosyl-1,4-diazepane is used as a protein kinase A inhibitor for the treatment of hepatitis. Its application is based on its ability to inhibit the activity of protein kinase A, which plays a role in the development and progression of hepatitis. By inhibiting this enzyme, 1,4-ditosyl-1,4-diazepane may help alleviate the symptoms and improve the overall condition of patients suffering from hepatitis.
Additionally, 1,4-ditosyl-1,4-diazepane may be used in medicinal combinations to enhance the therapeutic effects of other drugs used in hepatitis treatment. Its synergistic action with other compounds can potentially lead to better treatment outcomes and improved patient recovery.
Check Digit Verification of cas no
The CAS Registry Mumber 5769-35-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,6 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5769-35:
(6*5)+(5*7)+(4*6)+(3*9)+(2*3)+(1*5)=127
127 % 10 = 7
So 5769-35-7 is a valid CAS Registry Number.
5769-35-7Relevant articles and documents
Unconventional Synthetic Process of Fasudil Hydrochloride: Costly Homopiperazine Was Avoided
Zhao, Jianhong,Wang, Dingding,Yang, Wu-Lin,Niu, Jinming,Wu, Weiting
, p. 91 - 96 (2021/12/06)
An efficient, robust, and cost-effective synthetic process of fasudil hydrochloride 1 was developed. Starting from readily available ethylenediamine and 5-isoquinoline sulfonyl chloride, the target product 1 was prepared through a six-step reaction, including sulfonamidation, protection, nucleophilic substitution, deprotection, cyclization, and salification. The process afforded 1 in 67.1% overall yield (based on 5-isoquinoline sulfonyl chloride) with 99.94% purity. Compared to the earlier published methodologies, the use of homopiperazine or its derivatives as intermediates was avoided. The salient features of this environmentally friendly synthetic route include easily available starting materials and operational simplicity, which could be suitable for large-scale industrial production.
