5771-00-6

Basic information

• Product Name: N-(4-acetylphenyl)-2-(2-nitrophenoxy)acetamide
• Synonyms: acetamide, N-(4-acetylphenyl)-2-(2-nitrophenoxy)-; N-(4-Acetylphenyl)-2-(2-nitrophenoxy)acetamide
• CAS NO: 5771-00-6
• Molecular Formula: C₇H₉N₃
• Molecular Weight: 314.2928
• Mol File: 5771-00-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 596.1°C at 760 mmHg
• Flash Point: 314.3°C
• Density: 1.341g/cm³
• Vapor Pressure: 3.55E-14mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: N-(4-acetylphenyl)-2-(2-nitrophenoxy)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-acetylphenyl)-2-(2-nitrophenoxy)acetamide(5771-00-6)
• EPA Substance Registry System: N-(4-acetylphenyl)-2-(2-nitrophenoxy)acetamide(5771-00-6)

Safety Data

• Hazardous Substances Data: 5771-00-6(Hazardous Substances Data)

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 60-34-4 methylhydrazine 

Downstream Products

• 5757-52-8 3-Methyl-5--1,3,4-thiadiazolidin-thion-2 
• 136514-99-3 5-(4-Chloro-phenyl)-2-methyl-6-pyridin-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazine-3-carboxylic acid methyl ester 
• 136514-98-2 5-(4-Methoxy-phenyl)-2-methyl-6-pyridin-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazine-3-carboxylic acid methyl ester 
• 136515-07-6 1-(2-Methyl-5-phenyl-6-pyridin-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-yl)-ethanone 
• 136515-10-1 1-Methyl-4,6-diphenyl-3-pyridin-2-yl-1,2,3,4-tetrahydro-[1,2,4,5]tetrazine 
• 148758-70-7 2-(1-methyl-5-phenyl-1H-[1,2,4]triazol-3-yl)-pyridine 

Relevant articles and documents

Copper complexes of tripodal κ6N-donor ligands: A structural, EPR spectroscopic and electrochemical study

A new tris(pyridylhydrazonyl)methane ligand, HC[N(Me)NC(H)Py]3 (L2) (Py = pyridyl), has been synthesized. The latter is accessible from triethyl orthoformate and 2-(2-methylhydrazono)methylpyridine in 63% isolated yield. We have investigated its coordination chemistry towards copper ions and compared the results with those obtained for the recently developed multifunctional ligand, (S)P[N(Me)NC(H)Py]3 (L1). The copper(II) complexes [Cu(L1)](OTf)2 (3) and [Cu(L2)](OTf)2 (4) (OTf = triflate, (O3SCF3)-) are mononuclear with the cations coordinated by three imino and three pyridine nitrogen atoms. Almost axial symmetric EPR spectra have been obtained in frozen solutions at X-band. The spectra show resolved hyperfine couplings to the copper nuclei on one of the three g values. X-ray structural analyses revealed in each case a cis bond distortion and a trigonal twist due to Jahn-Teller effects. The Cu II/CuI reduction potentials of 3 and 4 were shown to be remarkably low (E1/20 = -0.11 V for 3; E1/20 = -0.34 V for 4), especially for 3 consisting of the phosphorus supported ligand L1. The corresponding copper(I) complexes [Cu(L1)](OTf) (5) and [Cu(L2)](OTf) (6) are accessible by reduction using decamethyl ferrocene. Both copper(I) complexes have been characterized in detail including X-ray structure analyses.

Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives

A series of N-(imidazolidin-2-ylidene)hydrazones and N-(4,5-dihydro-1H- imidazol-2-yl)-N-methylhydrazones were prepared and examined for α1-, α2-adrenergic and imidazoline I 1, I2 receptors binding affinities as well as cytotoxic activity against human tumor cell lines. Among the compounds tested, 2-naphthaldehyde N-(imidazolidin-2-ylidene)hydrazone (3e) exhibited a significant affinity for both α2-adrenergic and imidazoline I1 receptors (Ki = 94.3 nM and IC50 = 51.7 nM, respectively). Moreover, pyridine-2-carboxaldehyde N-(imidazolidin-2-ylidene) hydrazone (3l) showed the highest binding affinity to α1- adrenoceptors (Ki = 24.6 nM), while quinoline-2-carboxaldehyde N-(imidazolidin-2-ylidene)hydrazone (3m) displayed the highest I2 affinity with a Ki value of 26.7 nM and a high selectivity with respect to α2-adrenergic and imidazoline I1 receptors (Ki = 22470.0 nM and IC50 = 6145.0 nM, respectively). None of the tested N-(4,5-dihydro-1H-imidazol-2-yl)-N- methylhydrazones 4p-u displayed cytotoxic activity.