57736-12-6

Basic information

• Product Name: 1-(3'-chlorophenyl)-3-phenylpropane-1,3-dione
• Synonyms: 1-(3'-chlorophenyl)-3-phenylpropane-1,3-dione
• CAS NO: 57736-12-6
• Molecular Weight: 258.704
• Mol File: 57736-12-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(3'-chlorophenyl)-3-phenylpropane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3'-chlorophenyl)-3-phenylpropane-1,3-dione(57736-12-6)
• EPA Substance Registry System: 1-(3'-chlorophenyl)-3-phenylpropane-1,3-dione(57736-12-6)

Safety Data

• Hazardous Substances Data: 57736-12-6(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 99-02-5 3'-Chloroacetophenone 
• 16616-38-9 1-(3-chlorophenyl)-3-phenyl-2-propyn-1-one 
• 932-90-1 Benzaldoxime 
• 93-89-0 benzoic acid ethyl ester 
• 2905-65-9 methyl 3-chlorobenzoate 
• 98-86-2 acetophenone 
• 1128-76-3 3-chloro-benzoic acid ethyl ester 

Downstream Products

• 7498-72-8 1-(3-chlorophenyl)-2-phenylethane-1,2-dione 
• 1045345-89-8 2-[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]-1-(3-chlorophenyl)-3-phenyl-1,3-propanedione 
• 57736-16-0 2-(3'-chlorophenyl)-3-benzoyl-4-phenyl-1-oxa-4-azabutadiene 
• 65-85-0 benzoic acid 
• 535-80-8 3-chlorobenzoate 

Relevant articles and documents

Rhodium-Catalyzed Aerobic Decomposition of 1,3-Diaryl-2-diazo-1,3-diketones: Mechanistic Investigation and Application to the Synthesis of Benzils

The conversion of 1,3-diaryl-2-diazo-1,3-diketones to 1,2-daryl-1,2-diketones (benzils) is reported based on a rhodium(II)-catalyzed aerobic decomposition process. The reaction occurs at ambient temperatures and can be catalyzed by a few dirhodium carboxylates (5 mol %) under a balloon pressure of oxygen. Moreover, an oxygen atom from the O2 reagent is shown to be incorporated into the product, and this is accompanied by the extrusion of a carbonyl unit from the starting materials. Mechanistically, it is proposed that the decomposition may proceed via the interaction of a ketene intermediate resulting from a Wolff rearrangement of the carbenoid, with a rhodium peroxide or peroxy radical species generated upon the activation of molecular oxygen. The proposed mechanism has been supported by the results from a set of controlled experiments. By using this newly developed strategy, a large array of benzil derivatives as well as 9,10-phenanthrenequinone were synthesized from the corresponding diazo substrates in varying yields. On the other hand, the method did not allow the generation of benzocyclobutene-1,2-dione from 2-diazo-1,3-indandione because of the difficulty of inducing the initial rearrangement.

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.

NOVEL COMPOUNDS

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.