5774-69-6 Usage
Description
Diethyl (benzyloxy)methylmalonate is an organic compound that serves as a crucial intermediate in various chemical syntheses. It is characterized by its chemical structure, which includes a malonate core with diethyl and benzyloxymethyl substituents. This unique structure endows it with specific reactivity and properties that make it valuable in the field of organic chemistry.
Uses
Used in Asymmetric Synthesis:
Diethyl (benzyloxy)methylmalonate is used as an intermediate in the asymmetric synthesis of (R)-(-)-chlozolinate through a chemoenzymatic procedure. Its role in this process is to provide a chiral center, which is essential for the production of enantiomerically pure compounds. This is particularly important in the pharmaceutical industry, where the desired biological activity is often associated with a specific enantiomer.
In the context of asymmetric synthesis, diethyl (benzyloxy)methylmalonate is used as a key building block for the creation of chiral molecules with a specific three-dimensional arrangement. This is crucial for the development of drugs with improved efficacy and reduced side effects, as the biological activity of many compounds is highly dependent on their stereochemistry.
Used in Pharmaceutical Industry:
Diethyl (benzyloxy)methylmalonate is also used in the pharmaceutical industry as a starting material for the synthesis of various chiral drugs. Its unique structure allows for the development of novel compounds with potential therapeutic applications. By leveraging the reactivity of diethyl (benzyloxy)methylmalonate, chemists can design and synthesize new drugs with improved pharmacological properties, such as increased potency, selectivity, and reduced toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 5774-69-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,7 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5774-69:
(6*5)+(5*7)+(4*7)+(3*4)+(2*6)+(1*9)=126
126 % 10 = 6
So 5774-69-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O5/c1-4-18-13(16)15(3,14(17)19-5-2)20-11-12-9-7-6-8-10-12/h6-10H,4-5,11H2,1-3H3
5774-69-6Relevant articles and documents
Asymmetric synthesis of (R)-(-)-chlozolinate through a chemoenzymatic procedure
Guanti, Giuseppe,Banfi, Luca,Powles, Katharine,Rasparini, Marcello,Scolastico, Carlo,Fossati, Novella
, p. 271 - 277 (2007/10/03)
A new asymmetric synthesis of (R)-chlozolinate 1, an important antifungal agent, based on the enzymatic asymmetrization of diethyl 2-benzyloxy-2-methylmalonate, is reported.
