577747-82-1Relevant articles and documents
Synthesis of Natural Ecteinascidins (ET-729, ET-745, ET-759B, ET-736, ET-637, ET-594) from Cyanosafracin B
Menchaca, Roberto,Martinez, Valentin,Rodriguez, Alberto,Rodriguez, Natividad,Flores, Maria,Gallego, Pilar,Manzanares, Ignacio,Cuevas, Carmen
, p. 8859 - 8866 (2007/10/03)
The semisynthetic process initially described for the synthesis of 1 (ET-743) has been extended to the preparation of other natural ecteinascidins. For the synthesis of 2 (ET-729) a demethylation of a N-Me intermediate was carried out by a selective oxidation with MCPBA. Other natural ecteinascidins (ET-745, ET-759B, ET-736, ET-637, ET-594) were accessible from key intermediate 25. The described methodologies allow for the preparation of a wide variety of ecteinascidins by procedures that can be easily scaled up.