57777-33-0

Basic information

• Product Name: 5-(CHLOROMETHYL)ISOXAZOLE
• Synonyms: 5-(CHLOROMETHYL)ISOXAZOLE;Isoxazole, 5-(chloromethyl)-;5-(chloromethyl)-1,2-oxazole
• CAS NO: 57777-33-0
• Molecular Formula: C4H4ClNO
• Molecular Weight: 117.53
• Mol File: 57777-33-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 200.1 °C at 760 mmHg
• Flash Point: 74.8 °C
• Appearance: /
• Density: 1.261 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.58±0.50(Predicted)
• CAS DataBase Reference: 5-(CHLOROMETHYL)ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(CHLOROMETHYL)ISOXAZOLE(57777-33-0)
• EPA Substance Registry System: 5-(CHLOROMETHYL)ISOXAZOLE(57777-33-0)

Safety Data

• Hazardous Substances Data: 57777-33-0(Hazardous Substances Data)

Usage

General Description

5-(Chloromethyl)isoxazole is a chemical compound with the molecular formula C4H4ClNO. It is a white crystalline solid that is used as a building block in organic synthesis. 5-(Chloromethyl)isoxazole is a chlorinated derivative of isoxazole, a five-membered aromatic heterocycle. It is mainly used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical drugs. Additionally, it has potential applications in the development of agrochemicals, dyes, and other fine chemicals. The chloromethyl group in the structure of 5-(Chloromethyl)isoxazole makes it a useful reagent for the introduction of the isoxazole ring into other organic compounds. Overall, 5-(Chloromethyl)isoxazole is a versatile chemical with various applications in the field of organic chemistry and drug development.

Upstream product

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Relevant articles and documents

HETEROCYCLIC GLP-1 AGONISTS

This disclosure relates to GLP-1 agonists of Formula (I), including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents

A series of N-heterocyclic indolyl glyoxylamides were synthesized and evaluated for in vitro and in vivo anticancer activities. They exhibited a broad spectrum of anticancer activity not only in murine leukemic cancer cells but also in human gastric, breast, and uterus cancer cells as well as their multidrug resistant sublines with a wide range of IC50 values. They also induced apoptosis and caused DNA fragmentation in human gastric cancer cells. Among the compounds studied, 7 showed the most potent activity of growth inhibition (IC50 17-1711 nM) in several human cancer cells. Given orally, compounds 7 and 13 dose-dependently prolonged the survival of animals inoculated with P388 leukemic cancer cells. N-Heterocyclic indolyl glyoxylamides may be useful as orally active chemotherapeutic agents against cancer and refractory cancerous diseases of multidrug resistance phenotype.