577775-45-2

Basic information

• Product Name: 3-methyl-1-oxo-2-phenyl-1H,5H-pyrido[1,2-a]benzimidazole-4-carbonitrile
• Synonyms: 3-methyl-1-oxo-2-phenyl-1H,5H-pyrido[1,2-a]benzimidazole-4-carbonitrile
• CAS NO: 577775-45-2
• Molecular Weight: 299.332
• Mol File: 577775-45-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-methyl-1-oxo-2-phenyl-1H,5H-pyrido[1,2-a]benzimidazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-1-oxo-2-phenyl-1H,5H-pyrido[1,2-a]benzimidazole-4-carbonitrile(577775-45-2)
• EPA Substance Registry System: 3-methyl-1-oxo-2-phenyl-1H,5H-pyrido[1,2-a]benzimidazole-4-carbonitrile(577775-45-2)

Safety Data

• Hazardous Substances Data: 577775-45-2(Hazardous Substances Data)

Upstream product

• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 5413-05-8 ethyl 2-phenylacetoacetate 

Downstream Products

• 577775-46-3 1-chloro-3-methyl-2-phenylpyrido[1,2-a]benzimidazole-4-carbonitrile 

Relevant articles and documents

Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan synthesis

Based on the HTS hit compound 1a, an inhibitor of β-1,6-glucan synthesis, we synthesized novel pyridobenzimidazole derivatives and evaluated their antifungal activity. Among the compounds synthesized, we identified the potent compound 15e, which exhibits

IMIDAZO(1,2-a)PYRIDINE DERIVATIVE

A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.