57808-65-8 Usage
Description
Closantel is a synthetic anti-parasitic agent that is effective against liver flukes, blood-sucking nematodes, and larval stages of certain arthropods in sheep and cattle. Its mechanism of action involves decoupling mitochondrial oxidative phosphorylation, which inhibits the production of ATP and, consequently, the energy generation of the parasites, leading to their death. Closantel is characterized by its white to light yellow powder appearance.
Uses
Used in Veterinary Medicine:
Closantel is used as an anti-parasitic agent for the treatment and prevention of infections caused by various parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum, and Strongyloides papillosus in cattle and sheep. Its application in this industry is due to its effectiveness in targeting and eliminating parasites that can cause significant health issues and economic losses in livestock.
Additionally, Closantel may have potential applications in other industries, such as pharmaceuticals, for the development of new drugs targeting similar mechanisms of action. However, based on the provided materials, the primary use of Closantel is within the veterinary medicine industry.
References
http://www.interchemie.com/veterinary-medicines/closan-50.html
Check Digit Verification of cas no
The CAS Registry Mumber 57808-65-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,8,0 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 57808-65:
(7*5)+(6*7)+(5*8)+(4*0)+(3*8)+(2*6)+(1*5)=158
158 % 10 = 8
So 57808-65-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)
57808-65-8Relevant articles and documents
The preparation method of the [...]
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Paragraph 0033-0036, (2019/07/04)
The invention discloses a method for preparing [...], which belongs to the chemical pharmaceutical intermediates preparation method technical field, the use of P-acetonitrile, O-nitro-P-chlorotoluene and 2 - hydroxy - 3, 5 - diiodosalicylic benzoic acid as the raw material, by condensation reaction, the reduction reaction and re-condensation reaction, then in the sodium hydroxide solution the salifiable preparation 2 - (trifluoromethyl) pyridine - 3 - formaldehyde. The method of the invention, adopting a relatively friendly reducing agent to replace the iron powder such as iron and waste water and the like to avoid the emission of pollutants, and simplifying the post-treatment, the improved process simple and safe operation, mild reaction conditions, the product yield is relatively high, less "wastes", has high industrial value.