578727-28-3

Basic information

• Product Name: Benzoic acid, 4-fluoro-, 2-ethyl-2-(phenylsulfonyl)hydrazide
• CAS NO: 578727-28-3
• Molecular Formula: C15H15FN2O3S
• Molecular Weight: 322.36
• Mol File: 578727-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-fluoro-, 2-ethyl-2-(phenylsulfonyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-fluoro-, 2-ethyl-2-(phenylsulfonyl)hydrazide(578727-28-3)
• EPA Substance Registry System: Benzoic acid, 4-fluoro-, 2-ethyl-2-(phenylsulfonyl)hydrazide(578727-28-3)

Safety Data

• Hazardous Substances Data: 578727-28-3(Hazardous Substances Data)

Upstream product

• 456-06-4 4-fluorobenzoyl hydrazide 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 360-23-6 N-benzenesulfonyl-N'-(4-fluoro-benzoyl)-hydrazine 
• 75-03-6 ethyl iodide 

Downstream Products

• 578727-32-9 C₁₅H₁₄ClFN₂O₂S 

Relevant articles and documents

Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-Diarylimidazoles

The synthesis and the pharmacological activity of a series of 1,5-diarylimidazoles developed as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in human whole blood) and in vivo (carrageenan-induced paw edema, air-pouch, and hyperalgesia tests). Modification of all the positions of two regioisomeric imidazole cores led to the identification of 4-[4-chloro-5-(3-fluoro4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide (UR-8880, 51f) as the best candidate, which is now undergoing Phase I clinical trials.