57882-27-6

Basic information

• Product Name: 2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: ASINEX-REAG BAS 13706539;IFLAB-BB F1981-0006;AKOS BBS-00000318;2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID;Zinc00312247;2-(2-pyridyl)-4-quinolinecarboxylic acid;2-(2-Pyridyl)cinchoninic acid;2-(2-Pyridyl)cinchoninsaeure [German]
• CAS NO: 57882-27-6
• Molecular Formula: C₁₅H₁₀N₂O₂
• Molecular Weight: 250.25
• Mol File: 57882-27-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 472 °C at 760 mmHg
• Flash Point: 239.2 °C
• Appearance: tan solid
• Density: 1.332 g/cm³
• Vapor Pressure: 1.03E-09mmHg at 25°C
• CAS DataBase Reference: 2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID(57882-27-6)
• EPA Substance Registry System: 2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID(57882-27-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 57882-27-6(Hazardous Substances Data)

Usage

General Description

The chemical 2-Pyridin-2-yl-quinoline-4-carboxylic acid is a heterocyclic compound with potential anti-cancer properties. It belongs to the class of quinoline carboxylic acids and is known for its ability to inhibit the growth of cancer cells by targeting specific molecular pathways. 2-PYRIDIN-2-YL-QUINOLINE-4-CARBOXYLIC ACID has been studied for its potential use in cancer therapy and has shown promise in preclinical studies. Additionally, 2-Pyridin-2-yl-quinoline-4-carboxylic acid has also been investigated for its antibacterial and antiviral properties, making it a versatile molecule with potential therapeutic applications in multiple fields.

InChI:InChI=1/C15H10N2O2/c18-15(19)11-9-14(13-7-3-4-8-16-13)17-12-6-2-1-5-10(11)12/h1-9H,(H,18,19)/p-1

Upstream product

• 1122-62-9 2-acetylpyridine 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 110435-56-8 N-phenyl-2-(pyridin-2-yl)quinoline-4-carboxamide 
• 778647-51-1 2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide 
• 778647-55-5 2-pyridin-2-yl-quinoline-4-carboxylic acid (3-cyclohexyliminomethyleneamino-propyl)-methyl-amide 
• 778647-48-6 2-pyridin-2-yl-quinoline-4-carboxylic acid [2-(3-cyclohexyl-thioureido)-ethyl]-amide 
• 778647-54-4 2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(3-cyclohexyl-thioureido)-propyl]-methyl-amide 
• 778647-45-3 2-pyridin-2-yl-quinoline-4-carboxylic acid [2-(4-fluoro-3-nitro-benzoylamino)-ethyl]-amide 
• 879919-34-3 N-(4-methoxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide 
• 1351929-44-6 N-(4-(dimethylamino)phenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide 
• 879919-40-1 2-(pyridin-2-yl)-N-p-tolylquinoline-4-carboxamide 
• 1232808-64-8 N-(4-hydroxyphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide 
• 1351929-57-1 N-(4-(methylamino)phenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide 
• 1351929-58-2 N-(4-(hydroxymethyl)phenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide 
• 1416579-72-0 5-[5-(2-pyridyl)-4-azaphthalimido]isophthalic acid 
• 1416579-73-1 5-[5-(2-pyridyl)-4-azaphthalimido]isophthaloyl dichloride 

Relevant articles and documents

A simple preparation of a functionalized diimine ligand: 2-(2-pyridyl)- 4-carboxyquinoline

A convenient single step preparation of the carboxylate functionalized diimine ligand, 2-(2-pyridyl)-4-carboxyquinoline 1 from isatin 2 and 2- acetylpyridine 3 is reported.

Synthesis, characterization, electrochemical and theoretical study of substituted phenyl-terpyridine and pyridine-quinoline based mixed chelate ruthenium complexes

In the present work, we report two methoxy-substituted phenyl-terpyridine ruthenium complexes with pyridine carboxyquinoline and NCS as ancillary ligands, [Ru(OMePhtpy)(pcqH)(NCS)](PF6) (1) and [Ru(triOMePhtpy)(pcqH)(NCS)](PF6) (2) (

Comparative study of the affinity and metabolism of type i and type II binding quinoline carboxamide analogues by cytochrome P450 3A4

Compounds that coordinate to the heme-iron of cytochrome P450 (CYP) enzymes are assumed to increase metabolic stability. However, recently we observed that the type II binding quinoline carboxamide (QCA) compounds were metabolically less stable. To test if the higher intrinsic clearance of type II binding compounds relative to type I binding compounds is general for other metabolic transformations, we synthesized a library of QCA compounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, and aromatic hydroxylation. The results demonstrated that type II binding QCA analogues were metabolically less stable (2- to 12-fold) at subsaturating concentration compared to type I binding counterparts for all the transformations. When the rates of different metabolic transformations between type I and type II binding compounds were compared, they were found to be in the order of N-demethylation > benzylic hydroxylation> O-demethylation > aromatic hydroxylation. Finally, for the QCA analogues with aza-heteroaromatic rings, we did not detect metabolism in aza-aromatic rings (pyridine, pyrazine, pyrimidine), indicating that electronegativity of the nitrogen can change regioselectivity in CYP metabolism.