579489-71-7

Basic information

• Product Name: 3-[4-(2-benzhydryloxy-ethyl)-piperazin-1-yl]-1-thiophen-2-yl-propan-1-one
• CAS NO: 579489-71-7
• Molecular Weight: 434.602
• Mol File: 579489-71-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[4-(2-benzhydryloxy-ethyl)-piperazin-1-yl]-1-thiophen-2-yl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(2-benzhydryloxy-ethyl)-piperazin-1-yl]-1-thiophen-2-yl-propan-1-one(579489-71-7)
• EPA Substance Registry System: 3-[4-(2-benzhydryloxy-ethyl)-piperazin-1-yl]-1-thiophen-2-yl-propan-1-one(579489-71-7)

Safety Data

• Hazardous Substances Data: 579489-71-7(Hazardous Substances Data)

Upstream product

• 60703-69-7 1-[2-(diphenylmethoxy)ethyl]piperazine 
• 13196-35-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one 
• 88-15-3 2-Acetylthiophene 

Relevant articles and documents

Further exploration of 1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}piperazine (GBR 12909): Role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter

A series of N-aromatic, N-heteroaromatic, and oxygenated N-phenylpropyl derivatives of 1-(2-benzhydryloxyethyl)-piperazine and 1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}piperazine, analogues of GBR 12909 (1a) and 12935 (1b), was synthesized and examined for their dopamine (DAT) and serotonin (SERT) transporter binding properties. One of these compounds, racemic 3-[4-(2-benzhydryloxyethyl)piperazin-1-yl]-1-(3-fluorophenyl)-propan-1-ol (33), had DAT affinity as good as, or better than, GBR 12909 and 12935, and was more selective for DAT over SERT than the GBR compounds. Both trans- (43) and cis- (47) (±)-2-(4-{2-[bis-(4-fluorophenyl)-methoxy]ethyl}piperazin-1- ylmethyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol had relatively good SERT selectivity and, as well, showed high affinity for SERT.