57956-49-7

Basic information

• Product Name: {(1-methoxy-3-phenylprop-1-en-1-yl)oxy}trimethylsilane
• Synonyms: {(1-methoxy-3-phenylprop-1-en-1-yl)oxy}trimethylsilane
• CAS NO: 57956-49-7
• Molecular Weight: 236.386
• Mol File: 57956-49-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: {(1-methoxy-3-phenylprop-1-en-1-yl)oxy}trimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: {(1-methoxy-3-phenylprop-1-en-1-yl)oxy}trimethylsilane(57956-49-7)
• EPA Substance Registry System: {(1-methoxy-3-phenylprop-1-en-1-yl)oxy}trimethylsilane(57956-49-7)

Safety Data

• Hazardous Substances Data: 57956-49-7(Hazardous Substances Data)

Upstream product

• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 21453-26-9 dimethyl 2-benzyl-3-phenylpentanedioate 
• 1616973-15-9 3-benzyl-4-phenyl-1-tosyl-1H-pyrrol-2(5H)-one 
• 1616973-23-9 (E)-methyl 2-benzyl-4-(4-methylphenylsulfonamido)-3-phenylbut-3-enoate 
• 1605291-25-5 methyl 2-(3,5-dichlorophenylamino)-3-phenylpropanoate 
• 1605291-18-6 methyl 3-(3,5-dichlorophenylamino)-3-phenylpropanoate 
• 1605291-24-4 methyl 2-(4-nitrophenylamino)-3-phenylpropanoate 
• 1605291-17-5 N-4-nitrophenyl-β-phenylalanine methyl ester 
• 1605291-23-3 methyl 3-phenyl-2-{[4-(trifluoromethyl)phenyl]amino}propanoate 
• 1605291-16-4 methyl 3-(4-(trifluoromethyl)phenylamino)-3-phenylpropanoate 
• 1605291-22-2 methyl 2-(3,5-bis(trifluoromethyl)phenylamino)-3-phenylpropanoate 

Relevant articles and documents

Reaction of silyl ketene acetals with epoxides: A new method for the synthesis of γ-butanolides

Titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides, followed by acidic work-up, affords butanolides in moderate/good yields. With epihalohydrins the reaction is regioselective and occurs at the less substituted end of the epoxide; the γ-haloalkyl-γ-butanolides thus obtained can be further transformed into various products. Graphical Abstract

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2- arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-Aminophenyl)-2- carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist

(E)-3-(2-Carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid, 1, is a potent and selective antagonist of the glycine site of the N-methyl-D-aspartate (NMDA) receptor. Using 3D comparative molecular field analysis (CoMFA) to guide the synthetic effort, a series of aryl diacid analogues of 1 were synthesized to optimize in vivo potency, duration of action, and binding activity. It was found that the incorporation of a substituted aromatic with an electron withdrawing group or a heterocyclic group at the 2-position of the 3-propenyl moiety of 1 gave compounds with better affinity and potency in the murine stroke model. Ultimately this led to the discovery of 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, 19, as a new potent selective glycine-site NMDA receptor antagonist.

Reaction of Silyl Enol Ethers with Arenediazonium Salts. Part 2. α-Amination of Esters

Diazonium salts efficiently serve as electrophilic aminating reagents of esters.The reaction of arenediazonium tetrafluoroborates with ketene silyl ketals yielded α-azo or α-hydrazono esters in good to excellent yields under very mild conditions.Hydrogenation of those esters gave α-amino esters quantitatively.