57963-11-8Relevant articles and documents
NOVEL BICYCLIC HETEROCYCLIC COMPOUND
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Paragraph 0600; 0601, (2018/09/27)
Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.
Synthesis of two potential heterocyclic amine food mutagens
Tanga, Mary J.,Kozocas, Joseph A.,Tochimoto, Todd K.
, p. 661 - 665 (2008/09/21)
(Chemical Equation Presented) The syntheses of two potential food mutagens formed during cooking, 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-b]pyridine (1) and 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-c]pyridine (2), are described.
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Hagmann,Caldwell,Chen,Durette,Esser,Lanza,Kopka,Guthikonda,Shah,MacCoss,Chabin,Fletcher,Grant,Green,Humes,Kelly,Luell,Meurer,Moore,Pacholok,Pavia,Williams,Wong
, p. 1975 - 1978 (2007/10/03)
A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.