57965-06-7

Basic information

• Product Name: Hydrazinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, ethyl ester
• CAS NO: 57965-06-7
• Molecular Formula: C11H15N3O3
• Molecular Weight: 237.258
• Mol File: 57965-06-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Hydrazinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, ethyl ester(57965-06-7)
• EPA Substance Registry System: Hydrazinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, ethyl ester(57965-06-7)

Safety Data

• Hazardous Substances Data: 57965-06-7(Hazardous Substances Data)

Upstream product

• 22003-17-4 O-phenyl N-benzylcarbamate 
• 4114-31-2 ethylhydrazine carboxylate 
• 100-46-9 benzylamine 
• 85210-15-7 1-ethyl 2-phenyl hydrazine-1,2-dicarboxylate 
• 124068-97-9 4‐nitrophenyl N‐benzylcarbamate 
• 3173-56-6 benzyl isothiocyanate 

Downstream Products

• 16312-86-0 4-benzyl-1,2,4-triazolidine-3,5-dione 

Relevant articles and documents

Sustainable synthesis routes towards urazole compounds

Sustainable synthesis routes towards urazoles, the precursor molecules for triazolinediones, are reported. Not only is the use of isocyanates avoided, but the applied synthetic procedures are also mostly solvent-free, high yielding and performed in an equimolar manner. Two complementary synthesis routes have been developed starting from a wide range of amines, both based on the use of diphenyl carbonate. The first method, which is particularly suitable for the synthesis of bulk urazoles, such as butyl, cyclohexyl or benzyl urazole, is performed in bulk in a one-pot fashion and generally results in yields between 87% and 96%. The second synthesis route, with yields up to 95%, focusses on the implementation of functionalities in the urazole structure and offers the possibility to generate bifunctional urazole compounds.

Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives

Betulin, a naturally occurring abundant triterpene is converted in four steps to 3,28-di-O-acetyllupa-12,18-diene. When various 4-substituted urazoles were oxidized to the corresponding urazines with iodobenzene diacetate in the presence of 3,28-di-O-acetyllupa-12,18-diene, new heterocyclic betulin derivatives were produced. These betulin derivatives were examined in a microplate assay at 50 μM for their ability to inhibit the growth of Leishmania donovani axenic amastigotes, a species that causes the fatal visceral leishmaniasis. GI50 (concentration for 50% growth inhibition) values of the most effective compounds were determined and their cytotoxicity on the human macrophage cell line THP-1 evaluated. The anti-leishmanial activity on L. donovani amastigotes growing in macrophages was also examined. The heterocycloadduct between 3,28-di-O-acetyllupa-12,18-diene and 4-methylurazine was the most effective derivative with an GI50 = 8.9 μM against L. donovani amastigotes.