57982-77-1

Basic information

• Product Name: Buserelin
• Synonyms: (d-ser(bu(supt)(sup6)))-lh-rh(1-9)nonapeptide-ethylamide;(d-ser(tbu)(sup6)-ea(sup10))-lhrh;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormon;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormone;d-ser(tbu(sup6))-lh-rh-(1-9)-nonapeptideethylamide;d-ser-(tbu)(sup6)-lhrh-ethylamide;etilamide;hoe766a
• CAS NO: 57982-77-1
• Molecular Formula: C60H86N16O13
• Molecular Weight: 1239.42
• EINECS: 261-061-9
• Product Categories: hormones
• Mol File: 57982-77-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 845.19°C (rough estimate)
• Appearance: COA
• Density: 1.0711 (rough estimate)
• Refractive Index: 1.6200 (estimate)
• Solubility: Sparingly soluble in water and in dilute acids.
• PKA: 9.82±0.15(Predicted)
• CAS DataBase Reference: Buserelin(CAS DataBase Reference)
• NIST Chemistry Reference: Buserelin(57982-77-1)
• EPA Substance Registry System: Buserelin(57982-77-1)

Safety Data

• Hazardous Substances Data: 57982-77-1(Hazardous Substances Data)

Usage

Description

Buserelin, also known by its brand name Suprefact (Hoechst-Roussel), is a synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH). It is a white or slightly yellowish powder with hygroscopic properties. Buserelin functions as a potent inhibitor of gonadotropin secretion, making it a valuable compound in various medical applications.

Uses

Used in Pharmaceutical Industry:
Buserelin is used as a therapeutic agent for the treatment of certain hormone-dependent conditions, such as prostate cancer and central precocious puberty. It works by initially stimulating and then suppressing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a decrease in testosterone and estrogen levels, respectively.
Used in Research Applications:
In the field of medical research, Buserelin is utilized as a research tool to study the effects of GnRH on the reproductive system and to investigate the role of gonadotropins in various physiological processes. It can also be used to assess the efficacy of other drugs targeting the GnRH receptor.
Used in Veterinary Medicine:
Buserelin is employed as a veterinary drug for the management of reproductive disorders in animals, such as the treatment of hormone-dependent conditions in dogs and cats. It helps regulate hormone levels and can be used to control the reproductive cycle in certain species.

Clinical Use

Treatment of advanced prostate cancer and endometriosis Pituitary desensitisation in preparation for ovulation induction regimens using gonadotrophins

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

Metabolic inactivation by peptides occurs in the liver and kidney. The drug is also inactivated by pituitary membrane enzymes. Excreted in the urine and bile as unchanged drug and metabolites.

InChI:InChI=1/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1