580-48-3Relevant articles and documents
Synthesis and spectral properties of triazine-based dendritic dithienylethenes
Cheng, Chuanjie,Liu, Zhongbin,Shen, Liang,Li, Long,Ma, Cha,Pu, Shouzhi,Xu, Jingkun
, p. 282 - 287 (2011)
Two novel triazine-based dendrimers comprising a dithienylethene core and eight and 16 ethyl groups around the periphery were synthesised in high yields in a convergent way, without using tedious protection and chromato-graphic separation steps. Their optical properties such as photochromism, fluorescence emission and film-forming behaviour were investigated. The new symmetrical dendritic dithienylethenes showed typical photochromic behaviour in solution and good film-forming performance in a poly(methyl methacrylate) (PMMA) matrix. Moreover, the dendrimers have demonstrated remarkable fluorescence enhancement and good solubility in common organic solvents, compared with the corresponding small molecule diarylethene. Thus, the new dendrimers as optoelectronic materials, have potential applications in optical storage, photo-switches, and so on.
Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives
Bhat, Hans Raj,Ghosh, Surajit Kumar,Masih, Anup,Shakya, Anshul,Singh, Udaya Pratap
, (2019/12/27)
A series of 4-aminoquinoline 1,3,5-triazine derivatives were synthesized and evaluated for anticancer activity against cancer cell lines HeLa, MCF-7, HL-60, HepG2 where these derivatives exert significant anticancer activity. The molecules found nontoxic against MCF-12A. The molecules also showed potent inhibition of EGFR-TK as compared to eroltinib in enzyme-based assay. The newly synthesized derivatives were screened for their in vitro antibacterial and antifungal activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, Aspergillus niger, Aspergillus fumigatus using cefixime and fluconazole as standard. Antibacterial screening results suggest that compound 7c showed potent activity against S. aureus, P. aeruginosa, and P. vulgaris. In antifungal screening, compound 7b showed significant activity against A. niger, A. fumigatus and moderate activity against C. albicans.
Triazine-pyrimidine based molecular hybrids: Synthesis, docking studies and evaluation of antimalarial activity
Kumar, Deepak,Khan, Shabana I.,Ponnan, Prija,Rawat, Diwan S.
supporting information, p. 5087 - 5095 (2015/02/19)
A series of novel triazine-pyrimidine hybrids have been synthesized and evaluated for their in vitro antimalarial activity. Some of the compounds showed promising antimalarial activity against both CQ-sensitive and CQ-resistant strains at micromolar level with a high selectivity index. All the compounds displayed better activity (IC50 = 1.32-10.70 μM) than the standard drug pyrimethamine (>19 μM) against the chloroquine-resistant strain W2. All the tested compounds were nontoxic against mammalian cell lines. Further, docking studies of the most active compounds were performed on both wild type and quadruple mutant (N51I, C59R, S108N, I164L) PfDHFR-TS using Glide to analyse the interaction of the compounds with the binding site of the protein. The binding poses of compounds 14 and 19, having a high Glide XP score and the lowest Glide energies, show an efficient binding pattern similar to that of the DHFR substrate (dihydrofolate) in the wild type and mutant DHFR active site. The analysis of the pharmacokinetic properties of the most active compounds using ADMET prediction attests to the possibility of developing compound 14 as a potent antimalarial lead. This journal is
