580-82-5

Basic information

• Product Name: 3,3'-Bis(trifluoroMethyl)-1,1'-biphenyl
• Synonyms: 3,3'-Bis(trifluoroMethyl)-1,1'-biphenyl
• CAS NO: 580-82-5
• Molecular Formula: C₁₄H₈F₆
• Molecular Weight: 290.2037392
• Mol File: 580-82-5.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,3'-Bis(trifluoroMethyl)-1,1'-biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-Bis(trifluoroMethyl)-1,1'-biphenyl(580-82-5)
• EPA Substance Registry System: 3,3'-Bis(trifluoroMethyl)-1,1'-biphenyl(580-82-5)

Safety Data

• Hazardous Substances Data: 580-82-5(Hazardous Substances Data)

Upstream product

• 98-08-8 α,α,α-trifluorotoluene 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 2042-37-7 o-cyanobromobenzene 
• 591-87-7 Allyl acetate 
• 13295-90-4 2-methyl-2-cyclohexen-1-yl acetate 
• 76644-52-5 rac-3-acetoxycyclohexene 
• 108-24-7 acetic anhydride 
• 1722-10-7 3-chloro-6-methoxypyridazine 
• 7440-66-6 zinc 
• 10166-09-3 (o-tolyl)acetyl chloride 
• 121899-80-7 tris(3-trifluoro-methylphenyl)bismuthane 
• 98-15-7 3-chlorotrifluoromethylbenzene 

Downstream Products

• 363-95-1 4,4'-dinitro-3,3'-bis-trifluoromethyl-biphenyl 

Relevant articles and documents

Optimizing the Mizoroki–Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups

Though a widely used metal-catalyzed cross-coupling process, the Mizoroki–Heck (MH) reaction can be a capricious transformation. This is particularly true for oxidation-prone alkene substrates containing ligating heteroatoms, as in the case of N-alkyl tetrahydropyridines, whose MH reactions have been underexplored due to the many side reactions that hamper the process. Since the products of tetrahydropyridine Heck reactions are direct precursors to potent pharmacophores, and therefore of commercial value, this is a significant drawback. We report here the results of our study designed to deliver an optimized, scalable MH procedure for N-alkyltetrahydropyridines and its exemplification in a gram-scale synthesis of the drug substance preclamol.

Iron-catalyzed homocoupling of aryl halides and derivatives in the presence of alkyllithiums

Direct synthesis of biaryl derivatives from aryl halides takes place under very mild temperature conditions by using a ligand-free iron catalytic system. The procedure, which proceeds via an in situ quantitative aryl halide exchange with alkyllithiums, allows for excellent control of the reactivity and is in line with the sustainable development. The method is also applicable to styryl and benzyl halides and to phenylacetylene.

Synthesis of functionalized 2-arylthiophenes with triarylbismuths as atom-efficient multicoupling organometallic nucleophiles under palladium catalysis

Atom-efficient cross-coupling reactions of functionalized 2-bromo- and 2-iodothiophenes have been demonstrated using triarylbismuths as atom-efficient multicoupling organometallic nucleophiles under palladium-catalyzed conditions. These couplings with various functionalized triarylbismuths proceeded smoothly to afford the corresponding functionalized 2-arylthiophenes in high yields. Georg Thieme Verlag Stuttgart · New York.