58003-06-8Relevant articles and documents
NONCATALEPTIC NEUROLEPTIC AGENTS: SYNTHESIS OF SOME ESTERS OF 2-CHLORO-10-(4-(2-HYDROXYETHYL)PIPERAZINO)-10,11-DIHYDRODIBENZOTHIEPIN
Jilek, Jiri,Valchar, Martin,Pomykacek, Josef,Dlabac, Antonin,Protiva, Miroslav
, p. 1503 - 1508 (2007/10/02)
Reaction of 2-chloro-10-(4-(2-hydroxyethyl)piperazino)-10,11-dihydrodibenzothiepin (I) with phenylacetic, methoxyacetic, methyltioacetic, phenoxyacetic and morpholinoacetic acid in dichlormethane and in the presence of N,N'-carbonyldiimidazole gave the title esters II-VI.Reaction of I with succinic anhydride affordet the hemisuccinate VII.The esters prepared elicited ataxia in low doses, were low-cataleptic, but only II, IV, and VII proves some antidopaminergic activity in the test using affecting dopamine metabolism in rat brain striatum.