58004-79-8

Basic information

• Product Name: Ethanone, 2-bromo-1-(5-pyrimidinyl)-
• Synonyms: Ethanone, 2-bromo-1-(5-pyrimidinyl)-;Ethanone, 2-bromo-1-(5-pyrimidinyl)- (9CI);2-BroMo-1-(pyriMidin-5-yl)ethanone;2-Bromo-1-(5-Pyrimidinyl)Ethanone
• CAS NO: 58004-79-8
• Molecular Formula: C6H5BrN2O
• Molecular Weight: 201.0207
• Product Categories: ACETYLHALIDE
• Mol File: 58004-79-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 279.9±15.0 °C(Predicted)
• Appearance: /
• Density: 1.666±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 0.92±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 2-bromo-1-(5-pyrimidinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-1-(5-pyrimidinyl)-(58004-79-8)
• EPA Substance Registry System: Ethanone, 2-bromo-1-(5-pyrimidinyl)-(58004-79-8)

Safety Data

• Hazardous Substances Data: 58004-79-8(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-bromo-1-(5-pyrimidinyl)-, also known as 2-Bromo-4-pyrimidinyl methyl ketone, is a chemical compound with the molecular formula C7H5BrN2O. It is a yellowish solid that is used in the synthesis of pharmaceuticals and agrochemicals. Ethanone, 2-bromo-1-(5-pyrimidinyl)- is also used as an intermediate in the production of various organic compounds. It is important to handle this chemical with caution as it may cause skin and eye irritation and is harmful if ingested or inhaled. It is advisable to use proper protective equipment and handle it in a well-ventilated area.

Upstream product

• 10325-70-9 1-(pyrimidin-5-yl)ethan-1-one 

Relevant articles and documents

A 2-amino-thiazole compounds (by machine translation)

The present invention relates to the technical field of pharmaceutical chemistry, particularly relates to a 2-amino thiazole compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)

Diarylthiazole: An antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system

Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize the potency and physicochemical properties. The effort led to more than 10 compounds with submicromolar MICs and desirable physicochemical properties. The potent antimycobacterial activity, in conjunction with low molecular weight, made the series an attractive lead (antibacterial ligand efficiency (ALE) >0.4). The series exhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb. Mutational analysis showed that mutations in prrB impart resistance to DAT compounds but not to reference drugs tested. The sensor kinase PrrB belongs to the PrrBA two component system and is potentially the target for DAT. PrrBA is a conserved, essential regulatory mechanism in Mtb and has been shown to have a role in virulence and metabolic adaptation to stress. Hence, DATs provide an opportunity to understand a completely new target system for antimycobacterial drug discovery.