58012-09-2Relevant articles and documents
Identification of a non peptidic RANTES antagonist
Bright, Colin,Brown, Thomas J.,Cox, Paul,Halley, Frank,Lockey, Peter,McLay, Iain M.,Moore, Una,Porter, Barry,Williams, Robert J.
, p. 771 - 774 (1998)
A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50 = 3 μM) was found to inhibit specific binding of 125I-RANTES, but not 125I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells.