58083-14-0

Basic information

• Product Name: L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(2-nitro-1-phenylethyl)-
• CAS NO: 58083-14-0
• Molecular Formula: C16H22N2O6S
• Molecular Weight: 370.426
• Mol File: 58083-14-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(2-nitro-1-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(2-nitro-1-phenylethyl)-(58083-14-0)
• EPA Substance Registry System: L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(2-nitro-1-phenylethyl)-(58083-14-0)

Safety Data

• Hazardous Substances Data: 58083-14-0(Hazardous Substances Data)

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 5153-67-3 nitrostyrene 
• 20887-95-0 N-(tert-Butyloxycarbonyl)-L-cysteine 

Downstream Products

• 111902-59-1 S-<(RS)-2-amino-1-phenylethyl>-N-(tert-butoxycarbonyl)-L-cysteine 
• 110221-35-7 tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate 
• 110221-36-8 (S)-2-((2S,6R)-4-tert-Butoxycarbonylmethyl-5-oxo-2-phenyl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester 
• 110221-51-7 α-<(2R,6R)-6-<<(S)-1-carboxy-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetic acid 
• 110221-52-8 (S)-2-((2S,6R)-4-Carboxymethyl-5-oxo-2-phenyl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid 
• 110221-31-3 (S)-2-((2S,6R)-5-Oxo-2-phenyl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester 
• 110143-56-1 (2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one 
• 110143-55-0 (2R,6R)-6-amino-2-phenylperhydro-1,4-thiazepin-5-one 
• 110221-25-5 (2S,6R)-6-amino-2-phenylperhydro-1,4-thiazepin-5-one 
• 110221-42-6 α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetic acid hydrochloride 
• 110221-43-7 (S)-2-((2S,6R)-4-Carboxymethyl-5-oxo-2-phenyl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride 
• 110143-54-9 (2RS,6R)-6-<(tert-butoxycarbonyl)amino>-2-phenylperhydro-1,4-thiazepin-5-one 

Relevant articles and documents

Angiotensin-Converting Enzyme Inhibitors: Perhydro-1,4-thiazepin-5-one Derivatives

α-amino>-5-oxoperhydro-1,4-thiazepin-4-yl>acetic acids (monoester monoacids) and their dicarboxylic acids having the hydrophobic substituents at the 2- or 3-position of the thiazepinone ring were prepared and assayed for angiotensin-converting enzyme (ACE) inhibitory activity.The dicarboxylic acids having the pseudoequatorial amino groups at the 6-position and the pseudoequatorial hydrophobic substituents at the 2- or 3-position of the chair conformation of the thiazepinone ring had potent in vitro inhibitory activity.The monoester monoacids having the hydrophobic substituents at the 2-position suppressed pressor response to angiotensin I for a longer duration than those having the substituents at the 3-position when administered orally.The structure-activity relationship was studied by conformational energy calculations of the thiazepinone ring.