58084-22-3

Basic information

• Product Name: Benzamide, 2-iodo-N-methyl-
• CAS NO: 58084-22-3
• Molecular Formula: C8H8INO
• Molecular Weight: 261.062
• Mol File: 58084-22-3.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-iodo-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-iodo-N-methyl-(58084-22-3)
• EPA Substance Registry System: Benzamide, 2-iodo-N-methyl-(58084-22-3)

Safety Data

• Hazardous Substances Data: 58084-22-3(Hazardous Substances Data)

Upstream product

• 615-37-2 ortho-methylphenyl iodide 
• 609-67-6 2-Iodobenzoyl chloride 
• 593-51-1 methylamine hydrochloride 
• 88070-48-8 N-methylbenzamide 
• 88-67-5 2-Iodobenzoic acid 
• 74-89-5 methylamine 

Downstream Products

• 135781-45-2 2-<2-(N-methylcarbamoyl)phenylthio>benzoic acid 
• 110166-72-8 2-(2'-phenylethynyl)-N-methyl benzamide 
• 88070-48-8 N-methylbenzamide 
• 197141-57-4 N-methyl-1,2,3,4-tetrahydro-1-oxoisoquinoline-3-carboxylic acid 
• 198020-50-7 2-[(2'-trimethylsilylethynyl)-N-methyl]benzamide 
• 1439356-94-1 ethyl 6,7,8-trifluoro-2-(2-iodophenyl)-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1548561-18-7 N-methyl-2-(3-methyl-1H-indol-1-yl)benzamide 
• 1435940-01-4 C₁₇H₁₈N₂O 
• 349110-28-7 N-benzyl-2-iodo-N-methylbenzamide 
• 1551274-13-5 N-hexyl-2-iodo-N-methylbenzamide 
• 1551274-25-9 N-benzyl-N-methyl-2-(phenylethynyl)benzamide 
• 1551274-26-0 N-hexyl-N-methyl-2-(phenylethynyl)benzamide 
• 1551274-34-0 N-benzyl-N-methyl-2-(phenylethynyl)benzothioamide 
• 1551274-37-3 N-hexyl-N-methyl-2-(phenylethynyl)benzothioamide 

Relevant articles and documents

KOtBu-BF3.OEt2 mediated synthesis of quinazolin-4(3H)-ones from 2-substituted amides with nitriles and aldehydes

KOtBu-BF3.OEt2 mediated synthesis of quinazolin-4(3H)-ones from 2-substituted amides with nitriles and aldehydes have been developed. In this protocol, a variety of nitriles as well as aldehydes react with 2-substituted benzamides to corresponding quinazolin-4(3H)-ones products in good to moderate yields, via the cleavage of C-X and C-N bonds and the formation of double C-N bonds simultaneously, in presence of potassium tert-butoxide.

Nickel-catalyzed regioselective C-H halogenation of electron-deficient arenes

A straightforward Ni(ii)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed. This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described.

Palladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones

A new palladium-catalyzed tandem cyclization of various alkene-tethered aryl iodides has been presented. In this protocol, o-bromobenzoic acids are employed as coupling parters to achieve the insertion of aromatic rings by the cleavage of C(sp2)-Br and decarboxylation, thus assembling various dibenzoisoquinolinediones and dibenzoisoquinolinones. In addition, a seven-membered ring can be constructed by the use of 8-bromo-1-naphthoic acid. Notably, this approach enables regioselective product formation and features broad substrate scope.