5809-59-6Relevant articles and documents
Preparation method of 1-cyano-2-propenyl acetate
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Paragraph 0094-0102; 0108-0116; 0122-0130; 0136-0144; 0150, (2020/07/21)
The invention relates to a preparation method of 1-cyano-2-allyl acetate. The method comprises the following steps: (1) reacting hydrocyanic acid with acrolein in the presence of a first catalyst to obtain a reaction solution containing acrolein cyanohydrin; and (2) reacting the obtained reaction solution containing acrolein cyanohydrin with an esterifying agent in the presence of a second catalyst to obtain a reaction solution containing 1-cyano-2-propenyl acetate. The first catalyst and the second catalyst are the same or different and are respectively and independently N,N-dimethylaminopyridine carboxylate. According to the preparation method provided by the invention, the efficient catalyst N,N-dimethylaminopyridine carboxylate is used as a catalyst shared by two steps of reactions, and the two steps of main reactions can be efficiently catalyzed, so that the two steps of main reactions can be carried out according to an approximate stoichiometric ratio; the yield of the product 1-cyano-2-propenyl acetate can reach 99% or above, and the purity can reach 99.5% or above; and the investment is saved, and the product competitiveness is improved.
Preparation method of 2-hydroxyl-3-butene-1-amine
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Paragraph 0046; 0047; 0048; 0063; 0064; 0065, (2016/11/09)
The invention discloses a preparation method of 2-hydroxyl-3-butene-1-amine. The preparation method comprises the following specific steps: (1) taking acrolein as a start raw material to react with trimethylsilyl cyanide at room temperature in the presence of lithium perchlorate trihydrate to obtain 2-hydroxyl-3-butene-1-nitrile; (2) with diethyl ether or tetrahydrofuran as a solvent, reducing the 2-hydroxyl-3-butene-1-nitrile with lithium aluminum hydride to obtain a crude product of 2-hydroxyl-3-butene-1-amine; (3) making the crude product of 2-hydroxyl-3-butene-1-amine react with hydrochloric acid to obtain 2-hydroxyl-3-butene-1-amine hydrochloride; and (4) making the 2-hydroxyl-3-butene-1-amine hydrochloride react with alkali to finally obtain the 2-hydroxyl-3-butene-1-amine. According to the method disclosed by the invention, without a trimethylsilyl protection group removal process, the operation of reduced pressure distillation is avoided, the reaction path is shortened, and the operation is simple.
A single-step, mild, neutral, catalyst-free method for cyanohydrin synthesis
Degani, Mariam S.,Kakwani, Manoj D.,Palsule Desai, Nutan H.,Bairwa, Ranjeet
experimental part, p. 461 - 465 (2012/06/15)
A wide variety of carbonyl compounds can be transformed to their corresponding cyanohydrins in a single step using a dimethyl sulfoxide (DMSO)-water system in excellent yields (75-94%). The major advantages of this system are that the reaction conditions are mild and neutral; the reaction proceeds without catalyst and gives the corresponding cyanohydrins in short time (15-120 min).