58094-17-0

Basic information

• Product Name: 4,5,6,7-Tetrahydro-1-benzothiophen-4-amine
• Synonyms: 4,5,6,7-Tetrahydro-1-benzothiophen-4-amine
• CAS NO: 58094-17-0
• Molecular Formula: C₈H₁₁NS
• Molecular Weight: 153
• Mol File: 58094-17-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 258 °C at 760 mmHg
• Flash Point: 109.8 °C
• Appearance: /
• Density: 1.149 g/cm³
• Storage Temp.: 2-8°C
• PKA: 9.92±0.20(Predicted)
• CAS DataBase Reference: 4,5,6,7-Tetrahydro-1-benzothiophen-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-Tetrahydro-1-benzothiophen-4-amine(58094-17-0)
• EPA Substance Registry System: 4,5,6,7-Tetrahydro-1-benzothiophen-4-amine(58094-17-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 58094-17-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 18, p. 1511, 1953 DOI: 10.1021/jo50017a009

Upstream product

• 13414-95-4 4-keto-4,5,6,7-tetrahydrothianaphthene 
• 77287-34-4 formamide 
• 19995-19-8 4,5,6,7-tetrahydro-4-oxobenzo[b]thiophene oxime 
• 4653-11-6 2-thiophenebutyric acid 
• 4653-08-1 4-oxo-4-thiophen-2-yl-butyric acid 

Downstream Products

• 58094-06-7 N-formyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine 
• 58095-31-1 4,5,6,7-Tetrahydro-7-oxobenzothien-4-ylharnstoff 

Relevant articles and documents

ION CHANNEL INHIBITOR COMPOUNDS FOR CANCER TREATMENT

The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R′ is an -A1-Cy1 group, or R is an -A1-Cy1 group and R′ is an R1 group, R1 particularly being H or (C1-C6)alkyl group;A1 being an —NH— radical or —NH—CH2— radical;Cy1 particularly being a phenyl group,A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes

4,5,6,7-Tetrahydro-benzothiophen-7-ylamines, 4,5,6,7-tetrahydro- benzothiophen-4-ylamines, and 5,6-dihydro-4H-thieno[2,3-b] thiopyran-4- ylamines were designed, synthesized, and tested as OH radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were able to protect in vitro the astroglial glutamate transporters against inhibitory action of radicals promoted by xanthine/xanthine oxidase. Thus, such compounds might be useful for lowering the large amounts of excitotoxic glutamate liberated during acute CNS diseases: they might protect the glutamate reuptake in astrocytes from the inhibitory action due to radicals co-liberated with glutamate.