58137-45-4

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methyl-
• CAS NO: 58137-45-4
• Molecular Formula: C11H10ClN3O2
• Molecular Weight: 251.672
• Mol File: 58137-45-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methyl-(58137-45-4)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methyl-(58137-45-4)

Safety Data

• Hazardous Substances Data: 58137-45-4(Hazardous Substances Data)

Usage

General Description

2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methyl- is a chemical compound that belongs to the pyrimidine family. It has a molecular formula of C11H10ClN3O2 and a molecular weight of 247.67 g/mol. 2,4(1H,3H)-Pyrimidinedione, 6-[(4-chlorophenyl)amino]-3-methyl- is often used in the pharmaceutical industry as a building block for the synthesis of various drugs. It is also known for its potential antitumor and anticancer properties, and is being studied for its potential use in the treatment of cancer. Additionally, it has been investigated for its role in inhibiting certain enzymes and protein kinases, making it a promising candidate for drug development in various therapeutic areas.

Upstream product

• 106-47-8 4-chloro-aniline 
• 4318-56-3 3-methyl-6-chlorouracil 

Downstream Products

• 92978-35-3 ethyl 2,3,4,8-tetrahydro-3-methyl-2,4-dioxopyrido-7-phenyl-8-(4-chlorophenyl)<2,3-d>pyrimidine-6-carboxylate 
• 90987-50-1 8-Chloro-10-(4-chloro-phenyl)-3-methyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 130806-28-9 6-(4'-chloroanilino)-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione 
• 1079130-08-7 C₃₉H₅₀ClN₃O₂ 
• 130806-37-0 8-(4'-chlorophenyl)-3-methyl-6,7-diphenylpteridine-2,4(3H,8H)-dione 
• 130806-35-8 8-(4'-chlorophenyl)-3,6,7-trimethylpteridine-2,4(3H,8H)-dione 
• 130806-33-6 8-(4'-chlorophenyl)-3-methylpteridine-2,4(3H,8H)-dione 
• 130806-31-4 5-amino-6-(4'-chloroanilino)-3-methylpyrimidine-2,4(1H,3H)-dione 
• 69083-38-1 10-(4-chloro-phenyl)-3-methyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 92978-44-4 6-benzoyl-1,2,3,4,7,8-hexahydro-3-methyl-8(4-chlorophenyl)-2,4,7-trioxopyrido<2,3-d>pyrimidine 
• 92978-22-8 8-(4-Chloro-phenyl)-3-methyl-2,4-dioxo-7-phenyl-2,3,4,8-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid 
• 79157-27-0 10-(4-Chlorophenyl)-3,7-dimethylpyrido<2,3-d:6,5-d'>pyrimidine 
• 76896-39-4 C₂₉H₂₄Cl₂N₆O₄ 

Relevant articles and documents

Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds

Novel deazaflavin-cholestane hybrid compounds, 3′,8′-disubstituted-5′-deazacholest-2,4-dieno[2,3-g]pteridine-2′,4′(3′H,8′H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2,4(1H,3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines (CCRF-HSB-2 and KB cells) have been investigated in vitro, and many of these compounds showed promising antitumor activities. Furthermore, molecular docking study using LigandFit within the software package Discovery Studio 1.7 was done for lead optimization of these compounds as potential PTK inhibitors. In general, all of the synthesized steroid-hybrid compounds showed good binding affinities into PTK (PDB code: 1t46).

Flavins as Potential Antimalarials. 1. 10-(Halophenyl)-3-methylflavins

A series of 10-(halomethyl)-3-methylflavins was prepared by the condensation of 6-(haloanilino)-3-methyluracils with nitrosobenzene.A number of these flavins effectively cured lethal Plasmodium vinckei malarial infections in mice when administered by eith