58151-87-4Relevant articles and documents
Regioselective O2′,O3′-deacetylations of peracetylated ribonucleosides by using tetra-n-butylammonium fluoride
Babu Kumar, Arun,Manetsch, Roman
supporting information, p. 3551 - 3555 (2014/06/23)
A robust, mild, and highly regioselective deacetylation of 1,2-diol diacetates in the presence of other acetate functions was achieved by using tetra-n-butylammonium fluoride. This method provided a single-step route to access O5′-acetyl ribonucleosides, a key intermediate in the synthesis of biomedically important nucleosides and nucleotides. Moreover, it offered the general applicability of a non-enzymatic method for the selective deacetylation of peracetylated 2′-deoxyribonucleosides. Its synthetic utility was further demonstrated by the synthesis of molecules of biomedical interest by using this particular deacetylation reaction. Copyright
