58183-40-7

Basic information

• Product Name: Benzenepropanoyl chloride, 4-Methyl-
• Synonyms: Benzenepropanoyl chloride, 4-Methyl-;3-(4-Methylphenyl)propanoyl chloride
• CAS NO: 58183-40-7
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• Mol File: 58183-40-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenepropanoyl chloride, 4-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoyl chloride, 4-Methyl-(58183-40-7)
• EPA Substance Registry System: Benzenepropanoyl chloride, 4-Methyl-(58183-40-7)

Safety Data

• Hazardous Substances Data: 58183-40-7(Hazardous Substances Data)

Upstream product

• 1866-39-3 trans-p-methylcinnamic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 104-82-5 4-Methylbenzyl chloride 
• 7116-41-8 ethyl 3-(4-methylphenyl)propanoate 
• 1866-39-3 4-methylcinnamic acid 

Downstream Products

• 214618-42-5 1-(thiophen-2-yl)-3-(p-tolyl)propan-1-one 
• 106511-65-3 3-(4-methylphenyl)-1-(4’-methoxyphenyl)propan-1-one 
• 58183-41-8 [2-(3-p-Tolyl-propionylamino)-phenyl]-acetic acid 
• 20387-27-3 Bis--peroxid 
• 52345-23-0 1-Diazo-4-(4-methylphenyl)butan-2-one 
• 109419-02-5 Ethyl 5-(4-Methylphenyl)-3-oxopentanoate 
• 86373-58-2 4-(p-Methylhydrocinnamamido)benzoic acid, ethyl ester 
• 288310-94-1 1,1,1-trifluoro-4-(4-methylphenyl)butan-2-one 
• 808170-32-3 N-(2-benzoyl-4-nitrophenyl)-3-(4-methylphenyl)propionic acid amide 
• 808169-93-9 N-(4-amino-2-benzoylphenyl)-3-(4-methylphenyl)propionic acid amide 
• 155456-14-7 {(S)-1-[(2S,4R)-4-(4-Methyl-benzyl)-5-oxo-tetrahydro-furan-2-yl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 214286-57-4 1-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-3-p-tolyl-propan-1-one 
• 214286-90-5 {(S)-3-Methyl-1-[(2S,4R)-4-(4-methyl-benzyl)-5-oxo-tetrahydro-furan-2-yl]-butyl}-carbamic acid tert-butyl ester 
• 214286-89-2 [5-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-1-isobutyl-4-(4-methyl-benzyl)-5-oxo-pentyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Cyclohexyl-Fused, Spirobiindane-Derived, Phosphine-Catalyzed Synthesis of Tricyclic ?3-Lactams and Kinetic Resolution of ?3-Substituted Allenoates

A C2-symmetric chiral phosphine catalyst, NUSIOC-Phos, which can be easily derived from cyclohexyl-fused spirobiindane, was introduced. A highly enantioselective domino process involving pyrrolidine-2,3-diones and γ-substituted allenoates catalyzed by NUSIOC-Phos has been disclosed. Diastereospecific tricyclic γ-lactams containing five contiguous stereogenic centers were obtained in high yields and with nearly perfect enantioselectivities. A kinetic resolution process of racemic γ-substituted allenoates was developed for the generation of optically enriched chiral allenoates.

Regioselective intramolecular oxidation of phenols and anisoles by dioxiranes generated in situ

A novel method for regioselective oxidation of phenols and anisoles has been developed in which dioxiranes, generated in situ from ketones and Ozone, oxidize phenol derivatives in an intramolecular fashion. A series of ketones with electron-withdrawing groups, such as CF3, COOMe, and CH2Cl, were attached to phenols, anisoles, or aryl rings via a C2 or C3 methylene linker. In a homogeneous solvent system of CH3CN and H2O, oxidation of phenol derivatives 1-10 afforded spiro 2-hydroxydienones in 24-55% yields regardless of the presence of other substituents (ortho Me, meta Me or Br) on the aryl ring and the length of the linker. Experimental evidences were provided to support the mechanism that involves a regioselective π bond epoxidation of aryl rings followed by epoxide rearrangement and hemiketal formation.