582325-06-2

Basic information

• Product Name: 6-(4-Fluoro-phenyl)-2-methyl-nicotinic acid
• Synonyms: 6-(4-Fluoro-phenyl)-2-methyl-nicotinic acid
• CAS NO: 582325-06-2
• Molecular Formula: C₁₃H₁₀FNO₂
• Molecular Weight: 231.23
• Mol File: 582325-06-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(4-Fluoro-phenyl)-2-methyl-nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-Fluoro-phenyl)-2-methyl-nicotinic acid(582325-06-2)
• EPA Substance Registry System: 6-(4-Fluoro-phenyl)-2-methyl-nicotinic acid(582325-06-2)

Safety Data

• Hazardous Substances Data: 582325-06-2(Hazardous Substances Data)

Upstream product

• 31676-67-2 ethyl (2-methyl-6-4'-fluorophenyl)nicotinate 

Downstream Products

• 1000812-30-5 6-(4-fluorophenyl)-2-methyl-3-pyridinecarbonyl chloride 
• 744261-33-4 SB 782443 
• 744261-44-7 N-(1H-benzimidazol-6-yl)-6-(4-fluorophenyl)-2-methylnicotinamide 
• 582324-68-3 C₂₂H₁₆FN₃O 
• 1089671-55-5 C₂₀H₁₄FN₃OS 
• 744261-37-8 N-benzothiazol-5-yl-6-(4-fluorophenyl)-2-methylnicotinamide 
• 1089671-56-6 C₂₃H₂₁FN₄OS 
• 1089671-57-7 C₂₂H₁₉FN₄OS 
• 1089671-54-4 C₂₁H₁₆FN₃O₂ 
• 1089671-51-1 C₂₂H₁₈FN₃O 
• 744261-47-0 N-indazol-6-yl-6-(4-fluorophenyl)-2-methylnicotinamide 
• 1089671-53-3 C₂₁H₁₇FN₄O 
• 744261-45-8 6-(4-fluorophenyl)-2-methyl-N-(1-methyl-1H-benzimidazol-6-yl)nicotinamide 
• 1089671-52-2 C₂₁H₁₇FN₄O 

Relevant articles and documents

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1

6-Phenylnicotinamide (2) was previously identified as a potent TRPV1 antagonist with activity in an in vivo model of inflammatory pain. Optimization of this lead through modification of both the biaryl and heteroaryl components has resulted in the discovery of 6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazol-5-yl)nicotinamide (32; SB-782443) which possesses an excellent overall profile and has been progressed into pre-clinical development.