58236-70-7

Basic information

• Product Name: 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE
• Synonyms: 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE;5-BROMO-3-CHLOROPYRIDIN-2-OL;5-Bromo-3-chloro-2(1H)-pyridinone
• CAS NO: 58236-70-7
• Molecular Formula: C₅H₃BrClNO
• Molecular Weight: 208.44
• EINECS: -0
• Product Categories: Pyridine;Halides;Pyridines;Boronic Acid;Pyridine Series
• Mol File: 58236-70-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 199-202℃
• Boiling Point: 303.763 °C at 760 mmHg
• Flash Point: 137.511 °C
• Appearance: /Solid
• Density: 15.386 g/cm³
• Vapor Pressure: 0.00196mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.48±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE(58236-70-7)
• EPA Substance Registry System: 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE(58236-70-7)

Safety Data

• Hazardous Substances Data: 58236-70-7(Hazardous Substances Data)

Usage

Description

5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE is an organic compound characterized by its unique molecular structure, featuring a pyridine ring with a hydroxyl group at the 2nd position, a bromine atom at the 5th position, and a chlorine atom at the 3rd position. 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE is known for its potential applications in various chemical and pharmaceutical processes due to its distinct functional groups and reactivity.

Uses

Used in Pharmaceutical Industry:
5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE is used as a reagent for the synthesis of 2-pyridyl-α-toluenesulfonates, which are compounds with potential antimalarial properties. 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE plays a crucial role in the development of new drugs to combat malaria, a disease that affects millions of people worldwide.
In the synthesis process, 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE serves as a key intermediate, providing the necessary functional groups for the formation of the desired antimalarial agents. Its unique structure allows for further chemical modifications and optimizations, potentially leading to the discovery of more effective and safer treatments for malaria.
Overall, 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE is a valuable compound in the pharmaceutical industry, particularly in the development of novel antimalarial drugs. Its unique properties and reactivity make it an essential component in the ongoing efforts to combat this global health challenge.

InChI:InChI=1/C5H3BrClNO/c6-3-1-4(7)5(9)8-2-3/h1-2,4H

Upstream product

• 13466-35-8 3-chloro-2-hydroxypyridine 

Downstream Products

• 160599-70-2 2,5-dibromo-3-chloropyridine 

Relevant articles and documents

3-Chloropyridines, and their use in liquid-crystal mixtures

3-Chloropyridines, process for their preparation, and their use in liquid-crystal mixtures A 3-chloropyridine of the formula (I) STR1 in which the symbols have the following meaning: R1 and R2, independently of one another, are, for example, H or straight-chain or branched alkyl, A1, A2, A3 and A4 are identical or different and are, for example, 1,4-phenylene, pyrazine-2,5-diyl or trans-1,4-cyclohexylene, M1, M2, M3 and M4 are identical or different and are, for example, --O-- or --CO--O--, R3, R4, R6 and R7, independently of one another are, for example, H or straight-chain or branched alkyl, M5 is, for example, --O--CO-- or a single bond, k, l, m, n, o, p, q and r are zero or one, with the proviso that the sum k+m+p+r is less than 4 and greater than zero, can advantageously be employed as a component in ferroelectric liquid-crystal mixtures.