58261-88-4Relevant articles and documents
Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
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, (2008/06/13)
The disclosure is of methods of treating various skin disorders, including skin cancer, with compounds of novel 1α-hydroxy vitamin D4 and novel analogues, thereof, including 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4. Novel 1α-hydroxy vitamin D4 compounds and compounds of novel analogues suitable for use in the treatment of such disorders are also disclosed herein.
Chromyl Halide Oxidation of Steroid Alkenes
Barrett, Anthony G. M.,Barton, Derek H. R.,Tsushima, Tadahiko
, p. 639 - 642 (2007/10/02)
Ergosteryl acetate and CrO2F2 gave 3β-acetoxy-6α-fluoroergosta-7,22-dien-5α-ol.Cholesteryl acetate and CrO2Cl2 gave the α- and β-epoxides, the 5α-chloro-6-ketone, and both 5α,6β-chlorohydrins; cis-chlorohydrins were not detected.Cholesteryl acetate and CrO2F2 gave both epoxides and the 5α-fluoro-6β-alcohol.Unexpectedly, 9,11-dehydrotigogenin acetate and CrO2F2 gave only the 9,11-epoxides with the β-form predominating (5:1).The absence of cis-halogenohydrin formation from simple olefins and CrO2X2 (X = F, Cl) is in conflict with recent studies on acyclic and monocyclic alkenes.