58316-48-6

Basic information

• Product Name: 1,1',1'',1'''-[Methylenebis(2,4,6-trihydroxy-5,1,3-benzenetriyl)]tetrakisethanone
• Synonyms: 1,1',1'',1'''-[Methylenebis(2,4,6-trihydroxy-5,1,3-benzenetriyl)]tetrakisethanone
• CAS NO: 58316-48-6
• Molecular Formula: C₂₁H₂₀O₁₀
• Molecular Weight: 432.38
• Mol File: 58316-48-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 284–286°C
• Appearance: /
• CAS DataBase Reference: 1,1',1'',1'''-[Methylenebis(2,4,6-trihydroxy-5,1,3-benzenetriyl)]tetrakisethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1',1'',1'''-[Methylenebis(2,4,6-trihydroxy-5,1,3-benzenetriyl)]tetrakisethanone(58316-48-6)
• EPA Substance Registry System: 1,1',1'',1'''-[Methylenebis(2,4,6-trihydroxy-5,1,3-benzenetriyl)]tetrakisethanone(58316-48-6)

Safety Data

• Hazardous Substances Data: 58316-48-6(Hazardous Substances Data)

Usage

Preparation

Obtained by condensation of formaldehyde with 2,4-diacetylphloroglucinol (35%).

Upstream product

• 50-00-0 formaldehyd 
• 2161-86-6 2,4-diacetylphloroglucinol 
• 108-73-6 3,5-dihydroxyphenol 
• 33797-51-2 eschenmoser's salt 

Relevant articles and documents

Toward an efficient and eco-friendly route for the synthesis of dimeric 2,4-diacetyl phloroglucinol and its potential as a SARS-CoV-2 main protease antagonist: Insight from: In silico studies

As a consequence of the unavailability of an anti-viral drug for SARS-CoV-2, the prospect of developing an antiviral drug is of great importance in this current emergency of the COVID-19 pandemic era. To support the enduring research on the improvement of

Ortho-amidoalkylation of phenols via tandem one-pot approach involving oxazine intermediate

A new and efficient method for ortho-amidoalkylation of phenols via Mannich-type condensation with formaldehyde and lactams using recyclable solid acid catalyst is described. This is the first report for ortho-amidoalkylation of phenols by lactams via Mannich-type condensation. LC-ESI-MS/MS based mechanistic study revealed that reaction proceeds through o-quinone methide (o-QM) and an oxazine intermediate via tandem Knoevenagel condensation, formal [4 + 2]-Diels-Alder cycloaddition and acid catalyzed oxazine ring-opening.