58325-18-1

Basic information

• Product Name: (2,2-difluoropropyl)benzene
• CAS NO: 58325-18-1
• Molecular Formula: C₉H₁₀F₂
• Molecular Weight: 156.1725
• Mol File: 58325-18-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 165.4°C at 760 mmHg
• Flash Point: 41.6°C
• Density: 1.043g/cm³
• Vapor Pressure: 2.47mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: (2,2-difluoropropyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (2,2-difluoropropyl)benzene(58325-18-1)
• EPA Substance Registry System: (2,2-difluoropropyl)benzene(58325-18-1)

Safety Data

• Hazardous Substances Data: 58325-18-1(Hazardous Substances Data)

Usage

Description

(2,2-difluoropropyl)benzene, also known as 1,3-bis(2,2-difluoropropyl)benzene, is a chemical compound with the molecular formula C12H14F4. It is a colorless liquid with a faint, sweet odor and is commonly used as a solvent, intermediate, or raw material in organic synthesis. (2,2-difluoropropyl)benzene is considered to be moderately toxic and is a potential irritant to the skin, eyes, and respiratory system. It is also known to be a flammable liquid and should be handled with appropriate safety measures. This chemical is not known to occur naturally, but it can be synthesized through various chemical processes.

Uses

Used in Organic Synthesis Industry:
(2,2-difluoropropyl)benzene is used as a solvent for various organic reactions, facilitating the process and improving the yield of desired products. Its unique chemical properties, such as its difluoropropyl groups, make it a valuable intermediate in the synthesis of more complex organic compounds.
Used in Chemical Intermediates:
(2,2-difluoropropyl)benzene serves as a key intermediate in the production of various specialty chemicals, including pharmaceuticals, agrochemicals, and other fine chemicals. Its ability to participate in a wide range of chemical reactions makes it a versatile building block for the synthesis of target molecules.
Used in Raw Material Production:
As a raw material, (2,2-difluoropropyl)benzene is utilized in the manufacturing of various industrial products, such as polymers, coatings, and adhesives. Its unique properties, including its difluoropropyl groups, contribute to the performance characteristics of the final products, enhancing their properties and applications.

Upstream product

• 98-83-9 isopropenylbenzene 
• 13343-40-3 (2,2-difluoro-1-cyclopropyl)benzene 
• 13099-51-9 2,2-Dichlor-1-phenyl-propan 
• 16602-83-8 phenyl-acetone-methylhydrazone 
• 29443-57-0 1-phenyl-2,2-diiodopropane 
• 133932-45-3 (2,2-Difluoro-3-iodo-propyl)-benzene 
• 133932-46-4 (2,2-Difluoro-1-iodo-propyl)-benzene 
• 103-79-7 1-phenyl-acetone 
• 5171-99-3 (1-phenylpropan-2-ylidene)hydrazine 
• 34917-00-5 2-benzyl-2-methylmalonic acid 

Relevant articles and documents

Ag-Catalyzed Chemoselective Decarboxylative Mono- and gem-Difluorination of Malonic Acid Derivatives

Malonic acid derivatives have been successfully applied in a Ag-catalyzed decarboxylative fluorination reaction, providing an unprecedented route to either gem-difluoroalkanes or α-fluorocarboxylic acids by the judicious selection of base and solvent. This reaction features the use of readily available starting materials, tunable chemoselectivity and good functional group compatibility as well as gram-scale synthetic capability. The advantage of using malonic acid derivatives in this radical decarboxylative functionalization is further highlighted by the facile transformations of the α-fluorocarboxylic acid to valuable fluorine-containing compounds. Preliminary mechanistic studies suggest that an α-carboxylic acid radical is involved in this reaction.

Synthetic method of difluoromethyl compound

The invention discloses a synthetic method of a difluoromethyl compound. The synthetic method of the difluoromethyl compound comprises the following steps: selecting styrene derivatives as raw materials, selecting dichloromethane as a solvent and triethylamine trihydrofluoride as a fluorinating agent and carrying out sufficient reaction at the temperature of 70 to 90 DEG C in the presence of a hypervalent iodine reagent iodobenzene diacetate; after the reaction is ended, separating and purifying reaction liquid to obtain the difluoromethyl compound. The synthetic method disclosed by the invention has the advantages of reasonable process conditions, simple operation, short reaction time, stable conversion rate and yield and wide substrate range. By adopting the triethylamine trihydrofluoride as the fluorinating agent, convenience in treatment is realized and no metal catalyst is needed, so the synthetic method is a high-efficiency synthetic method for synthesizing the difluoromethyl.

Fluorination reactions in microreactors

The DAST-mediated conversion of a range of alcohols to the corresponding fluorides in a microstructured device is described. This safe, practical fluorination method will facilitate reactions currently challenging on large scale. The Royal Society of Chem