58349-17-0

Basic information

• Product Name: (S)-2-Amino-5-methoxytetralin Hydrochloride
• Synonyms: RT-1;(S)-2-AMINO-5-METHOXYTETRAHYDRONAPHTHALENE HCL;(S)-2-Amino-5-methoxytetrahydronaphthalene hydrochloride;(S)-2-Amino-5-methoxytetralin hydrochloride;4-tetrahydro-5-Methoxy-;(S)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-aMine hydrochloride;2-NaphthalenaMine, 1,2,3,4-tetrahydro-5-Methoxy-, hydrochloride, (2S)-;(2S)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride
• CAS NO: 58349-17-0
• Molecular Formula: C11H15NO.HCl
• Molecular Weight: 213.7
• Mol File: 58349-17-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 262-265 °C
• Boiling Point: 283.85℃[at 101 325 Pa]
• Appearance: /
• Storage Temp.: -196°C
• Water Solubility: 39.6g/L at 20℃
• CAS DataBase Reference: (S)-2-Amino-5-methoxytetralin Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Amino-5-methoxytetralin Hydrochloride(58349-17-0)
• EPA Substance Registry System: (S)-2-Amino-5-methoxytetralin Hydrochloride(58349-17-0)

Safety Data

• Hazardous Substances Data: 58349-17-0(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

(S)-5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine Hydrochloride is an intermediate for Rotigotine (R700700), which is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.

InChI:InChI=1/C11H15NO.ClH/c1-13-11-4-2-3-8-7-9(12)5-6-10(8)11;/h2-4,9H,5-7,12H2,1H3;1H/t9-;/m0./s1

Upstream product

• 80270-84-4 5-Methoxy-3,4-dihydro-1H-naphthalen-2-one O-methyl-oxime 
• 93-09-4 naphthalene-2-carboxylate 
• 117745-72-9 methyl 5-methoxy-1,2,3,4-tetrahydro-2-naphthoate 
• 53568-17-5 5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid 
• 5043-31-2 5-Methoxy-2-naphthoic acid 
• 1013-83-8 5-bromonaphthalene-2-carboxylic acid 
• 67878-76-6 5-bromo-2-naphthalenecarboxylic acid methyl ester 
• 1309876-80-9 benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate 
• 32940-15-1 5-methoxy-2-tetralone 

Relevant articles and documents

Alternative and straightforward synthesis of dopaminergic 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine was synthesized from 2-naphthoic acid in six steps with an overall yield of 27%. Following the reaction sequence, bromination, esterification, substitution with NaOMe in the presence of CuI, the Birch reducti