58471-53-7

Basic information

• Product Name: H-ASP-ASP-OH
• Synonyms: L-ASPARTYL-L-ASPARTIC ACID;H-ASP-ASP-OH;ASP-ASP;diaspartic acid;(S)-2-((S)-2-Amino-3-carboxypropanamido)succinic acid
• CAS NO: 58471-53-7
• Molecular Formula: C₈H₁₂N₂O₇
• Molecular Weight: 248.19
• Product Categories: Amino Acid Derivatives;Dipeptides;Dipeptides and Tripeptides;Peptides
• Mol File: 58471-53-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 587.7 °C at 760 mmHg
• Flash Point: 309.2 °C
• Appearance: /
• Density: 1.602 g/cm³
• Vapor Pressure: 2.47E-15mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: −20°C
• PKA: 2.77±0.10(Predicted)
• CAS DataBase Reference: H-ASP-ASP-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP-ASP-OH(58471-53-7)
• EPA Substance Registry System: H-ASP-ASP-OH(58471-53-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 58471-53-7(Hazardous Substances Data)

Usage

General Description

H-ASP-ASP-OH, also known as Aspartic acid, is a non-essential amino acid that plays a crucial role in protein synthesis and neurotransmitter function. It is a natural component of sugar substitutes and is often used in the food industry to enhance the flavor of certain products. Aspartic acid is also involved in the urea cycle, which is important for the removal of toxic ammonia from the body. Additionally, it has been found to have potential therapeutic effects in the treatment of neurodegenerative diseases, as it may help to protect brain cells from damage. However, high levels of aspartic acid have been linked to negative health effects, such as excitotoxicity and neuronal cell death. Overall, while aspartic acid is important for various physiological processes, its levels must be carefully regulated to avoid potential harm.

InChI:InChI=1/C8H12N2O7/c9-3(1-5(11)12)7(15)10-4(8(16)17)2-6(13)14/h3-4H,1-2,9H2,(H,10,15)(H,11,12)(H,13,14)(H,16,17)

Upstream product

• 4526-73-2 N-(O-benzyl-N-benzyloxycarbonyl-L-α-aspartyl)-L-aspartic acid dibenzyl ester 
• 56-84-8 L-Aspartic acid 
• 657-27-2 L-Lysine hydrochloride 

Downstream Products

• 118429-74-6 H-Asp(OBzl)-Asp(OBzl)-OBzl 
• 56-84-8 L-Aspartic acid 

Relevant articles and documents

Modelling of prebiotic synthesis and selection of peptides under isothermal conditions and thermal cycling mode

The model peptide synthesis from mixtures of amino acids was carried out under the thermal cycling and isothermal modes. The compositions of the obtained mixtures of products and the primary amino acid sequence of the synthesized peptides were determined by Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry in combination with high-performance liquid chromatography with the application of de novo sequencing of the synthesized products. The processes of abiogenous synthesis of peptides were shown to occur under relatively mild temperature conditions and give a substantially less number of peptides as compared with the possible statistical set. The evolution of the system takes place in the process of the synthesis in solid phase with the disappearance of a series of the most unstable peptides. The selection process with the formation of complementary peptides takes place in peptide synthesis under the thermal cyclic mode.

COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT

The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

The Relationship between Taste and Primary Structure of "Delicious Peptide" (Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala) from Beef Soup

"Delicious peptide" was reported to be as delicious as beef soup.The peptide and its fragments were synthesized to study its taste active sites. "Delicious peptide" was found to produce a umami and a sour taste.By preparing several di- or tripeptides composed of basic or acidic amino acids, we found that the taste of "delicious peptide" was produced by an interaction between the basic and the acidic fragments in the peptide.