58481-36-0

Basic information

• Product Name: 6-amino-5-(benzylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 6-amino-5-(benzylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 58481-36-0
• Molecular Weight: 260.296
• Mol File: 58481-36-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-amino-5-(benzylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-(benzylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione(58481-36-0)
• EPA Substance Registry System: 6-amino-5-(benzylamino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione(58481-36-0)

Safety Data

• Hazardous Substances Data: 58481-36-0(Hazardous Substances Data)

Upstream product

• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 60228-89-9 6-amino-1,3-dimethyl-5-{[1-phenylmeth-(E)-ylidene]-amino}-1H-pyrimidine-2,4-dione 

Downstream Products

• 70404-36-3 N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N,N'-dibenzylthiourea 
• 1807-85-8 7-benzyltheophylline 
• 75735-08-9 N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-benzyl-formamide 
• 75724-47-9 N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-benzylacetamide 
• 2879-15-4 8-benzyltheophylline 

Relevant articles and documents

Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors

Fragment-based drug design was used to identify Mycobacterium tuberculosis (Mtb) dihydrofolate reductase (DHFR) inhibitors. Screening of ligands against the Mtb DHFR enzyme resulted in the identification of multiple fragment hits with IC50 values in the range of 38–90 μM versus Mtb DHFR and minimum inhibitory concentration (MIC) values in the range of 31.5–125 μg/mL. These fragment scaffolds would be useful for anti-tubercular drug design.