58481-39-3

Basic information

• Product Name: 1-METHYL-3-ISOBUTYL-4-AMINOURACIL
• Synonyms: 1-METHYL-3-ISOBUTYL-4-AMINOURACIL;1-Isobutyl-3-Methyl-6-aMinouracil;NSC 70483;2,4(1H,3H)-PyriMidinedione,6-aMino-3-Methyl-1-(2-Methylpropyl)-;6-amino-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione
• CAS NO: 58481-39-3
• Molecular Formula: C₉H₁₅N₃O₂
• Molecular Weight: 197.23
• Product Categories: Amines;Heterocycles;Intermediates
• Mol File: 58481-39-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 146-148°C
• Boiling Point: 285.5 °C at 760 mmHg
• Flash Point: 126.4 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 0.0028mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: -20?C Freezer
• CAS DataBase Reference: 1-METHYL-3-ISOBUTYL-4-AMINOURACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-3-ISOBUTYL-4-AMINOURACIL(58481-39-3)
• EPA Substance Registry System: 1-METHYL-3-ISOBUTYL-4-AMINOURACIL(58481-39-3)

Safety Data

• Hazardous Substances Data: 58481-39-3(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C9H15N3O2/c1-6(2)5-12-7(10)4-8(13)11(3)9(12)14/h4,6H,5,10H2,1-3H3

Upstream product

• 56075-75-3 6-amino-1-isobutyl-1,3-dihydropyrimidine-2,4-dione 
• 77-78-1 dimethyl sulfate 
• 38014-54-9 1-isobutyl-3-methyl-urea 
• 372-09-8 cyanoacetic acid 

Downstream Products

• 54052-67-4 1-isobutyl-3-methyl-5-nitroso-6-amino uracil 
• 78033-18-8 5,6-diamino-1-isobutyl-3-methyl-1H-pyrimidine-2,4-dione 
• 63908-28-1 1-Methyl-3-isobutyl8-methylxanthin 
• 58481-29-1 7-(4-chloro-benzyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 58481-23-5 7-Benzyl-3-isobutyl-1-methylxanthine 
• 28822-58-4 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione 
• 132560-07-7 8-Ethyl-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 132560-08-8 3-Isobutyl-1-methyl-8-propyl-3,7-dihydro-purine-2,6-dione 
• 132560-10-2 3,8-Diisobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 132560-09-9 8-Butyl-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 68006-09-7 (3-isobutyl-1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid 
• 132560-20-4 7-(2,3-Dihydroxy-propyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 132560-17-9 7-Dimethoxymethyl-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 132560-21-5 3-(3-Isobutyl-1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-propionic acid 

Relevant articles and documents

Structure-activity relationships in a series of xanthine derivatives with antibronchoconstrictory and bronchodilatory activities

Thirty-one 1,3,7,8-substituted xanthine derivatives have been synthesized and evaluated for bronchodilator and anti-bronchoconstrictory activities in in vitro tracheal relaxation and in vivo bronchospasm inhibition models. Activity tests have been complemented with phosphodiesterase inhibition and toxicological data. Structure-activity relationships are discussed. Compound 21 (1,3-diisobutyl-8-methylxanthine) has been selected for further pharmacological development because of its good activity profile and favourable therapeutic index, which is 14- and 38-fold greater than that of theophylline and IBMX, respectively.