585571-74-0

Basic information

• Product Name: 2-Buten-1-one, 4-[(1-methyl-1H-indol-2-yl)methoxy]-1-phenyl-, (2E)-
• CAS NO: 585571-74-0
• Molecular Formula: C20H19NO2
• Molecular Weight: 305.376
• Mol File: 585571-74-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Buten-1-one, 4-[(1-methyl-1H-indol-2-yl)methoxy]-1-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Buten-1-one, 4-[(1-methyl-1H-indol-2-yl)methoxy]-1-phenyl-, (2E)-(585571-74-0)
• EPA Substance Registry System: 2-Buten-1-one, 4-[(1-methyl-1H-indol-2-yl)methoxy]-1-phenyl-, (2E)-(585571-74-0)

Safety Data

• Hazardous Substances Data: 585571-74-0(Hazardous Substances Data)

Upstream product

• 768-03-6 Phenyl vinyl ketone 
• 585571-70-6 2-(allyloxymethyl)-1-methyl-1H-indole 
• 37493-34-8 methyl 1-methyl-1H-indole-2-carboxylate 
• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 1485-22-9 (1-methyl-1H-indol-2-yl)-methanol 
• 1477-50-5 Indole-2-carboxylic acid 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 585571-72-8 3-[(1-methyl-1H-indol-2-yl)methoxy]propane-1,2-diol 

Downstream Products

• 912756-16-2 2-(9-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-4-yl)-1-phenylethanone 

Relevant articles and documents

Asymmetrie construction of polycyclic indoles through olefin cross-metathesis/intramolecular friedel-crafts alkylation under sequential catalysis

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New versatile route to the synthesis of tetrahydro-β-carbolines and tetrahydro-pyrano[3,4-b]indoles via an intramolecular Michael addition catalyzed by InBr3

A simple multistep synthetic strategy to 4-sub-stituted 1,2,3,4-tetrahydro-β-carboline and 1,3,4,9-tetrahydro-pyrano[3,4-b]indole derivatives starting from commercially available indole 2-carboxylic acid (5) is described. The final intramolecular Michael addition promoted by catalytic amount of InBr3 (5-10 mol %) provided the expected polycyclic compounds in excellent yields (up to 97%) both in anhydrous organic and aqueous media.