58562-33-7 Usage
Description
4-Hydroxyestrone-4-methyl ether is an endogenous estrogen metabolite that exists in an off-white to pale yellow solid form. It is a naturally occurring compound derived from the metabolism of estrogen and has been identified as a potential risk factor for the development of breast cancer.
Uses
Used in Pharmaceutical Industry:
4-Hydroxyestrone-4-methyl ether is used as a pharmaceutical compound for its potential role in the development of breast cancer. Its identification as a risk factor allows researchers and pharmaceutical companies to study its mechanisms and develop targeted therapies or preventive measures against breast cancer.
Used in Research and Development:
In the field of research and development, 4-hydroxyestrone-4-methyl ether serves as a valuable compound for understanding the complex interactions between estrogen metabolism and breast cancer. Its study can lead to the discovery of new biomarkers, therapeutic targets, and potential drug candidates for the treatment and prevention of breast cancer.
Used in Diagnostics:
4-Hydroxyestrone-4-methyl ether can be utilized as a diagnostic marker to identify individuals at a higher risk of developing breast cancer. By measuring the levels of this compound in a patient's body, healthcare professionals can assess the risk and implement appropriate preventive measures or early interventions.
Used in Toxicology and Environmental Studies:
As an endogenous estrogen metabolite, 4-hydroxyestrone-4-methyl ether can also be used in toxicology and environmental studies to understand the impact of environmental factors on estrogen metabolism and breast cancer risk. This can help in the development of strategies to minimize exposure to harmful substances and reduce the incidence of breast cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 58562-33-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,5,6 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 58562-33:
(7*5)+(6*8)+(5*5)+(4*6)+(3*2)+(2*3)+(1*3)=147
147 % 10 = 7
So 58562-33-7 is a valid CAS Registry Number.
InChI:InChI=1/C19H24O3/c1-19-10-9-12-11-5-7-16(20)18(22-2)14(11)4-3-13(12)15(19)6-8-17(19)21/h5,7,12-13,15,20H,3-4,6,8-10H2,1-2H3/t12-,13-,15+,19+/m1/s1
58562-33-7Relevant articles and documents
Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen
Teranishi,Kashihara,Fujii
, p. 615 - 621 (2007/10/03)
The introduction of an oxygen atom into the C-6 position of 4-hydroxyestrogen allowed for the selective methylation of the two phenolic hydroxyl groups. When the 6-oxo derivative of 4-hydroxyestrone was benzylated in ethanol, only the 3-monobenzyl ether was obtained without formation of the 4-monobenzyl ether. Moreover, the 6-carbonyl group was further reduced to methylene almost quantitatively in the reaction of 4-acetoxy-6-oxoestrone 3-benzyl ether derivative with sodium borohydride. Therefore, 4-methoxyestrogen was synthesized by essentially combining these two reactions. Copyright
Methylation of catechol estrogen with diazomethane
Teranishi,Fujii,Yamazaki,Miyabo
, p. 3309 - 3314 (2007/10/02)
Dynamic aspects of methylation of catechol estrogen with diazomethane were investigated by means of thin-layer chromatography. The methylation rate of the hydroxyl group at the C-3 position was almost the same as that of the C-2 hydroxyl group in the reaction of 2-hydroxyestrogen, and 2-3 times that of the C-4 hydroxyl group in the reaction of 4-hydroxyestrogen. In these experiments, the maximum yields of 2-methoxyestrone, 2-hydroxyestrone 3-methyl ether, 4-methoxyesterone and 4-hydroxyesterone 3-methyl ether were 32, 39, 13, and 70%, respectively. In addition, demethylation of catechol estrogen dimethyl ethers with boron tribromide and synthesis of 4-hydroxyestrone monomethyl ethers are described.
