586-22-1

Basic information

• Product Name: 3-fluoro-4-methoxypropiophenone
• Synonyms: 1-(3-fluoro-4-methoxyphenyl)propan-1-one;1-Propanone, 1-(3-fluoro-4-Methoxyphenyl)-;1-(3-Fluoro-4-methoxyphenyl)propan-1-one, 2-Fluoro-4-propanoylanisole;1-(3-Fluoro-4-methoxyphenyl)
• CAS NO: 586-22-1
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.2
• Product Categories: Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 586-22-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 83-85 °C
• Boiling Point: 278.5°Cat760mmHg
• Flash Point: 118.5°C
• Appearance: /
• Density: 1.099g/cm³
• Vapor Pressure: 0.00425mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-fluoro-4-methoxypropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-4-methoxypropiophenone(586-22-1)
• EPA Substance Registry System: 3-fluoro-4-methoxypropiophenone(586-22-1)

Safety Data

• Hazardous Substances Data: 586-22-1(Hazardous Substances Data)

Usage

Preparation

Obtained by reaction of propionyl chloride or propionic anhydride with 2-fluoroanisole in the presence of aluminium chloride in carbon disulfide.

InChI:InChI=1/C10H11FO2/c1-3-9(12)7-4-5-10(13-2)8(11)6-7/h4-6H,3H2,1-2H3

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 351-54-2 3-fluoro-p-anisaldehyde 
• 925-90-6 ethylmagnesium bromide 
• 1649-96-3 1-(3-fluoro-4-methoxyphenyl)propan-1-ol 
• 331-62-4 3-fluoro-4-methoxybenzonitrile 
• 2357-52-0 3-fluoro-4-methoxyphenyl bromide 
• 455-91-4 1-(3-fluoro-4-methoxyphenyl)ethanone 

Downstream Products

• 586-16-3 1-(3-fluoro-4-hydroxyphenyl)propan-1-one 
• 441-33-8 2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 577-74-2 6-chloro-2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 445-84-1 6-bromo-2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 442-11-5 2-(3-fluoro-4-methoxy-phenyl)-3-methyl-indole 
• 85720-35-0 cis-3,4-bis(3-fluoro-4-methoxyphenyl)hex-3-ene 
• 4394-62-1 α-Hydroxyimino-3-fluor-4-methoxy-propiophenon 
• 970-03-6 meso-3,4-bis(3-fluoro-4-hydroxyphenyl)hexane 
• 2249-64-1 meso-3,3'-difluorohexestrol dimethyl ether 
• 394-07-0 6-bromo-2-(3-fluoro-4-methoxy-phenyl)-3-methyl-quinoline 
• 4394-65-4 α-Amino-3-fluor-4-methoxy-propiophenon 
• 1010800-91-5 methyl 3-(3-fluoro-4-methoxyphenyl)-2-methyl-3-oxopropanoate 
• 1010800-75-5 4-(3-fluoro-4-methoxyphenyl)-3-methyl-4-oxobutanoic acid methyl ester 
• 1094101-93-5 4-(3-Fluoro-4-methoxyphenyl)-3-methyl-4-oxobutanoic acid 

Relevant articles and documents

DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation-Hydrogenolysis Strategy of Enaminones

A novel heterogeneous catalytic hydrogenation-hydrogenolysis strategy has been developed for the α-methylation of ketones via enaminones using DMF dimethyl acetal as carbon source. This strategy provides a very convenient route to α-methylated ketones using a variety of ketones without any base or oxidant. (Chemical Equation Presented).

NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS

The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.

PYRIDAZINONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.