58619-56-0

Basic information

• Product Name: 1-Piperazineacetonitrile(6CI,9CI)
• Synonyms: 1-Piperazineacetonitrile(6CI,9CI)
• CAS NO: 58619-56-0
• Molecular Formula: C₆H₁₁N₃
• Molecular Weight: 125.17164
• Product Categories: PIPERAZINE
• Mol File: 58619-56-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperazineacetonitrile(6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazineacetonitrile(6CI,9CI)(58619-56-0)
• EPA Substance Registry System: 1-Piperazineacetonitrile(6CI,9CI)(58619-56-0)

Safety Data

• Hazardous Substances Data: 58619-56-0(Hazardous Substances Data)

Usage

Derivative of piperazine

1-Piperazineacetonitrile is a modified version of the piperazine molecule, which is a heterocyclic organic compound.

Contains a cyano group

The presence of a cyano group (CN) in the molecule contributes to its nitrile functionality.

Nitrile functionality

The cyano group gives 1-Piperazineacetonitrile the properties of a nitrile, which is a chemical group with a triple bond between carbon and nitrogen.

Intermediate in synthesis

This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, meaning it is a reactant in the production of these compounds.

Building block in organic synthesis

1-Piperazineacetonitrile is used as a building block for the production of various molecules in organic synthesis.

Potential pharmaceutical applications

Due to its role as a precursor in the synthesis of bioactive compounds, 1-Piperazineacetonitrile has potential applications in the pharmaceutical industry.

Upstream product

• 676341-78-9 1-benzyloxycarbonyl-4-cyanomethylpiperazine 
• 110-85-0 piperazine 
• 107-14-2 chloroacetonitrile 
• 590-17-0 cyanomethyl bromide 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 916140-58-4 [4-(3-diphenylaminopropyl)piperazin-1-yl]acetonitrile 
• 916140-65-3 2-[4-(3-diphenylaminopropyl)piperazin-1-yl]ethylamine 
• 1272246-56-6 PZ₁₀₅₁-1 
• 1398718-01-8 (R)-1-amino-N-(1-cyano-2-(4'-((4-(cyanomethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide 

Relevant articles and documents

CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE UNCHARGED BISOXIME ANTIDOTES FOR ORGANOPHOSPHATE POISONING AND METHODS FOR MAKING AND USING THEM

In alternative embodiments, provided are uncharged bis-oxime antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). In alternative embodiments, provided are pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi-chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound as provided herein.

Process improvements for the preparation of kilo quantities of a series of isoindoline compounds

A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorder. The isoindoline compounds were prepared by reduction of the corresponding phthalimides with LiAlH4. One compound was not chiral, and the other two required an enantioselective synthesis. The key step for these optically active analogues involved the coupling by an SN2 process of either a piperazynyl intermediate or a piperdinyl intermediate with methyl 3-benzyloxy-2-trifluoromethansulfonatopropionate. The products for these two analogues had >98% ee. Process improvements led to the multi-kilogram syntheses of each of these compounds.