58626-97-4

Basic information

• Product Name: [4-(Methylthio)phenyl]-hydrazinehydrochloride
• Synonyms: [p-(Methylthio)phenyl]hydrazine hydrochloride
• CAS NO: 58626-97-4
• Molecular Formula: C₇H₁₀N₂S*ClH
• Molecular Weight: 190.69364
• Mol File: 58626-97-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 198-199℃
• Boiling Point: 305.7°C at 760 mmHg
• Flash Point: 138.7°C
• Appearance: /
• Vapor Pressure: 0.000806mmHg at 25°C
• CAS DataBase Reference: [4-(Methylthio)phenyl]-hydrazinehydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(Methylthio)phenyl]-hydrazinehydrochloride(58626-97-4)
• EPA Substance Registry System: [4-(Methylthio)phenyl]-hydrazinehydrochloride(58626-97-4)

Safety Data

• Hazardous Substances Data: 58626-97-4(Hazardous Substances Data)

Usage

General Description

[4-(Methylthio)phenyl]-hydrazinehydrochloride is a chemical compound that consists of a hydrazine moiety attached to a phenyl ring with a methylthio group. It is commonly used as a reagent in organic synthesis and pharmaceutical research. The hydrazine group in the compound has the potential to form hydrazones, which are useful intermediates in the synthesis of various organic compounds. The presence of the methylthio group adds additional reactivity to the molecule, making it a versatile building block for the preparation of diverse chemical products. The hydrochloride salt form of the compound makes it more stable and easier to handle in laboratory settings. Overall, [4-(Methylthio)phenyl]-hydrazinehydrochloride is a valuable chemical reagent with multiple applications in organic chemistry.

InChI:InChI=1/C7H10N2S.ClH/c1-10-7-4-2-6(9-8)3-5-7;/h2-5,9H,8H2,1H3;1H

Upstream product

• 115171-09-0 N,N'-bis-(t-butoxycarbonyl)-4-(methylthio)phenylhydrazine 
• 104-96-1 4-methylsulfanylaniline 
• 18620-04-7 4-thioanisolemagnesium bromide 
• 104-95-0 (4-bromophenyl)thioanisole 

Downstream Products

• 572912-93-7 1-[4-(methylthio)phenyl]pyrazole 
• 903902-68-1 2,3,4,5-tetrahydro-8-methylthio-2-(phenylmethyl)-1H-pyrido[4,3-b]indole 
• 616209-43-9 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole 
• 675605-72-8 1-(4-(methylsulfonyl)phenyl)-5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazole 
• 190711-47-8 1-(4-Methanesulfinyl-phenyl)-5-p-tolyl-3-trifluoromethyl-1H-pyrazole 
• 903902-86-3 5-tert-butoxycarbonyl-2,3,4,5-tetrahydro-8-methylthio-2-(phenylmethyl)-1H-pyrido[4,3-b]indole 
• 572912-94-8 1-[4-(methylthio)phenyl]pyrazole-5-carbaldehyde 
• 572912-95-9 1-[4-(methylsulfonyl)phenyl]pyrazole-5-carbaldehyde 
• 698350-38-8 1-(4-methylsulfonylphenyl)-5-(naphthalene-2-yl)-3-trifluoromethyl-1H-1,2,4-triazole 
• 101832-75-1 2-(5-methylsulfanyl-indol-3-yl)-ethylamine; hydrochloride 
• 1338216-18-4 C₁₈H₁₅F₃N₂OS 
• 1338216-19-5 C₁₉H₁₇F₃N₂OS 
• 1338216-20-8 1-(4-(methylthio)phenyl)-3-trifluoromethyl-5-(4-fluoro-2-methoxyphenyl)pyrazole 

Relevant articles and documents

Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

The N,N’-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 oC in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith

Compounds having the formula: STR1 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

ADDITION OF ARYLMETALLICS TO AZODICARBOXYLATES: A NOVEL SYNTHESIS OF ARYLHYDRAZINES BY AROMATIC HYDRAZINATION

Aryllithiums and arylmagnesium bromides add to the N=N bond of di-t-butyl azodicarboxylate, and subsequent acid deprotection provides the arylhydrazine.