58629-87-1

Basic information

• Product Name: FluoroMalonaldehydic Acid
• Synonyms: FluoroMalonaldehydic Acid;2-Fluoro-3-oxopropanoic Acid
• CAS NO: 58629-87-1
• Molecular Formula: C3H3FO3
• Molecular Weight: 106
• Product Categories: Aliphatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 58629-87-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: Aqueous Acid (Sparingly), Methanol (Very Slightly, Heated)
• Stability: Hygroscopic, Light Sensitive, Temperature Sensitive
• CAS DataBase Reference: FluoroMalonaldehydic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: FluoroMalonaldehydic Acid(58629-87-1)
• EPA Substance Registry System: FluoroMalonaldehydic Acid(58629-87-1)

Safety Data

• Hazardous Substances Data: 58629-87-1(Hazardous Substances Data)

Usage

Description

FluoroMalonaldehydic Acid is a degradation product derived from 2,2'-Anhydro-1-β-D-arabinofuranosyl-5-fluorocytosine and 1-β-D-Arabinofuranosyl-5-fluorocytosine in rats. It is known for its ability to be oxidized in vivo to fluoromalonic acid and ultimately to fluoroacetate, which are compounds that inhibit the Krebs cycle, a crucial metabolic pathway in cells.

Uses

Used in Pharmaceutical Industry:
FluoroMalonaldehydic Acid is used as an intermediate compound for the development of pharmaceuticals targeting the Krebs cycle. Its conversion to fluoromalonic acid and fluoroacetate allows for the inhibition of this cycle, which can be beneficial in the treatment of certain diseases and conditions.
Used in Research and Development:
FluoroMalonaldehydic Acid is used as a research compound to study the effects of Krebs cycle inhibition on cellular metabolism and its potential applications in therapeutic interventions. This can lead to the discovery of new drugs and treatment strategies for various medical conditions.
Used in Toxicology Studies:
FluoroMalonaldehydic Acid is used as a toxicological agent to investigate the effects of Krebs cycle inhibition on cellular processes and overall organism health. This can help in understanding the potential risks and side effects associated with the use of compounds that target the Krebs cycle.