58734-14-8

Basic information

• Product Name: N-(4-METHOXY-BENZOYL)-4-METHYL-BENZENESULFONAMIDE
• Synonyms: N-(4-METHOXY-BENZOYL)-4-METHYL-BENZENESULFONAMIDE;4-Methoxy-N-tosylbenzamide
• CAS NO: 58734-14-8
• Molecular Formula: C₁₅H₁₅NO₄S
• Molecular Weight: 305.3489
• Mol File: 58734-14-8.mol
• Article Data: 26

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.273g/cm³
• Refractive Index: 1.579
• CAS DataBase Reference: N-(4-METHOXY-BENZOYL)-4-METHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-METHOXY-BENZOYL)-4-METHYL-BENZENESULFONAMIDE(58734-14-8)
• EPA Substance Registry System: N-(4-METHOXY-BENZOYL)-4-METHYL-BENZENESULFONAMIDE(58734-14-8)

Safety Data

• Hazardous Substances Data: 58734-14-8(Hazardous Substances Data)

Usage

General Description

N-(4-Methoxy-benzoyl)-4-methyl-benzenesulfonamide, also known as Methyl 4-methoxybenzoylbenzenesulfonate, is a chemical compound commonly used in pharmaceuticals, dyes, and pigments. It is a white to yellowish crystalline substance, and its primary function is as an intermediate in the synthesis of various pharmaceutical ingredients. Its properties make it a useful building block in drug discovery and development. Additionally, it is used in the production of dyes and pigments due to its ability to impart color to a variety of materials. This chemical has applications in both the pharmaceutical and chemical industries and is an important compound for the development of various products.

InChI:InChI=1/C15H15NO4S/c1-11-3-9-14(10-4-11)21(18,19)16-15(17)12-5-7-13(20-2)8-6-12/h3-10H,1-2H3,(H,16,17)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 3424-93-9 4-methoxyphenylacetamide 
• 4083-64-1 Tosyl isocyanate 
• 70744-47-7 (p-methoxyphenyl)tri-n-butylstannane 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-66-3 methoxybenzene 
• 937-12-2 4-tolyltrimethylstannane 
• 70841-00-8 dibutyl di(p-methylphenyl)tin 
• 3532-17-0 4-methoxybenzoyl azide 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 123-11-5 4-methoxy-benzaldehyde 
• 127-65-1 chloroamine-T 
• 21849-40-1 dibromamine-T 

Downstream Products

• 1267588-27-1 3-tert-butoxycarbonylmethyl-5-methoxy-2-tosylisoindolin-1-one 
• 1360743-69-6 C₂₄H₂₂N₂O₄S 
• 1356832-69-3 3-ethoxycarbonyl-3-ethoxycarbonylmethyl-5-methoxy-2-tosylisoindolin-1-one 
• 1369577-04-7 5-methoxy-4'-methyl-N-(4-methylbenzenesulfonyl)biphenyl-2-carboxamide 
• 1267588-16-8 2,4-dimethoxy-N-(4-methylbenzenesulfonyl)benzenecarboxamide 
• 17483-29-3 2,4,6-trimethoxy-N-(4-methylbenzenesulfonyl)benzenecarboxamide 
• 18854-16-5 Anis-N-tosyl-imidchlorid 

Relevant articles and documents

Ru(ii)-catalyzed allenylation and sequential annulation of: N -tosylbenzamides with propargyl alcohols

We hereby report Ru(ii)-catalyzed C(sp2)-H allenylation of N-tosylbenzamides to access multi-substituted allenylamides. Furthermore, the allenylamides were converted to the corresponding isoquinolone derivatives via base mediated annulation. The current protocol features low catalyst loading, mild reaction conditions, high functional group compatibility and desired scalability. The unique functionality of the afforded allenes allowed further transformations to expand the practicality of the protocol. This journal is

Metal-free C-H Activation over Graphene Oxide toward Direct Syntheses of Structurally Different Amines and Amides in Water

Unprecedented metal-free synthesis of a variety of amines and amides is reported via amination of C(sp3)-H and C(sp2)-H bonds. The strategy involves graphene-oxide/I2-catalyzed nitrene insertion using PhINTs as a nitrene (NT) source in water at room temperature. A wide range of structurally different substrates, viz., cyclohexane, cyclic ethers, arenes, alkyl aromatic systems, and aldehydes/ketones, having an α-phenyl ring have been employed successfully to afford the corresponding nitrene insertion product in good yield, albeit low in few cases. The envisaged method has superiority over others in terms of its operational simplicity, metal-free catalysis, use of water as a solvent, ambient reaction conditions, and reusability of the catalyst.

Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.