58745-46-3

Basic information

• Product Name: (S)-N-(1-hydroxy-3-phenylpropan-2-yl)picolinamide
• Synonyms: (S)-N-(1-hydroxy-3-phenylpropan-2-yl)picolinamide
• CAS NO: 58745-46-3
• Molecular Weight: 256.304
• Mol File: 58745-46-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-N-(1-hydroxy-3-phenylpropan-2-yl)picolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(1-hydroxy-3-phenylpropan-2-yl)picolinamide(58745-46-3)
• EPA Substance Registry System: (S)-N-(1-hydroxy-3-phenylpropan-2-yl)picolinamide(58745-46-3)

Safety Data

• Hazardous Substances Data: 58745-46-3(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 1381861-17-1 C₁₇H₁₈N₂O₃ 
• 3182-95-4 L-Phenylalaninol 

Relevant articles and documents

Directing Group in Decarboxylative Cross-Coupling: Copper-Catalyzed Site-Selective C-N Bond Formation from Nonactivated Aliphatic Carboxylic Acids

Copper-catalyzed directed decarboxylative amination of nonactivated aliphatic carboxylic acids is described. This intramolecular C-N bond formation reaction provides efficient access to the synthesis of pyrrolidine and piperidine derivatives as well as the modification of complex natural products. Moreover, this reaction presents excellent site-selectivity in the C-N bond formation step through the use of directing group. Our work can be considered as a big step toward controllable radical decarboxylative carbon-heteroatom cross-coupling.

Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp2)-H amination

An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp2)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.