58754-97-5

Basic information

• Product Name: 2,2-DiMethoxy-N-(thiophen-3-ylMethyl)ethanaMine
• Synonyms: 2,2-DiMethoxy-N-(thiophen-3-ylMethyl)ethanaMine;2,2-dimethoxy-N-(thiophen-3-ylmethyl)ethan-1-amine
• CAS NO: 58754-97-5
• Molecular Formula: C₉H₁₅NO₂S
• Molecular Weight: 201.2859
• Mol File: 58754-97-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-DiMethoxy-N-(thiophen-3-ylMethyl)ethanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DiMethoxy-N-(thiophen-3-ylMethyl)ethanaMine(58754-97-5)
• EPA Substance Registry System: 2,2-DiMethoxy-N-(thiophen-3-ylMethyl)ethanaMine(58754-97-5)

Safety Data

• Hazardous Substances Data: 58754-97-5(Hazardous Substances Data)

Usage

Organic compound

Contains two methoxy groups, a thiophenylmethyl group, and an amine group

Use in organic synthesis and pharmaceutical research

Used as a starting material or intermediate for the production of various drugs and bioactive compounds

Potential pharmacological properties

Ability to interact with neurotransmitter receptors in the brain

Use as a reagent

In the chemical analysis of organic compounds

Upstream product

• 55390-13-1 C₉H₁₃NO₂S 
• 498-62-4 3-thiophene carboxaldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 

Downstream Products

• 59038-45-8 4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-7-ol 
• 58754-96-4 N-(2,2-dimethoxyethyl)-4-methyl-N-3-(thienylmethyl)benzenesulfonamide 
• 272-14-0 thieno[3,2-c]pyridine 
• 62019-65-2 5-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-7-ol 
• 568582-98-9 thieno[3,2-c]pyridin-2-yl-2-boronic acid 

Relevant articles and documents

Rho-kinase inhibitors

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

1-(Thienylalkyl)imidazole-2(3H)-thiones as potent competitive inhibitors of dopamine β-hydroxylase

1-(2-Thienylalkyl)imidazole-2(3H)-thiones (5a-k) are competitive inhibitors of dopamine β-hydroxylase (DBH) and demonstrate the utility of thiophene in the design of potent competitive inhibitors of this enzyme. The structure-activity relationships for these compounds are discussed and compared with those of 1-phenylalkylimidazole-2(3H)-thiones (1). With the aid of molecular modeling, an idealized active-site conformer is proposed and an explanation for the difference in activity between the phenyl (1) and thienyl (5) DBH inhibitors is presented. The difference in activity is consistent with our proposal that thiophene may not always be a bioisostere for phenyl. The inhibitor of most interest, 1-[2-(2-thienyl)ethyl]imidazole-2(3H)-thione (5g), was selected for study in the spontaneously hypertensive rat. The changes in dopamine and norepinephrine levels that resulted from oral administration of 5g correlated with the reduction of blood pressure.