58780-60-2

Basic information

• Product Name: α-methyldopa benzyl ester
• CAS NO: 58780-60-2
• Molecular Weight: 301.342
• Mol File: 58780-60-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α-methyldopa benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-methyldopa benzyl ester(58780-60-2)
• EPA Substance Registry System: α-methyldopa benzyl ester(58780-60-2)

Safety Data

• Hazardous Substances Data: 58780-60-2(Hazardous Substances Data)

Upstream product

• 555-30-6 methyldopa 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Synthesis of α-Methyldopa Prodrugs Containing Dipeptide Moieties as Tools for Intestinal Delivery

Dipeptides containing D-phenylglycine or D-p-hydroxyphenylglycine were attached onto the antihypertensive agent α-methyldopa to form prodrugs 1a,1b and 1c.The nonessential amino acids were introduced into the prodrug molecules as tools of chemical delivery to improve the intestinal absorption of the parent drug.Preliminary tests revealed that the prodrugs were stable in phosphate buffer solutions at pH 7.4(t1/2>10 h).These compounds also demonstrated satisfactory stability toward enzymatic degradation in a mucosa preparation isolated from rat intestine, indicating that they might be feasibly formulated as an oral prodrug of α-methyldopa.Key Words α-Methyldopa prodrugs; Dipeptides as tools for intestinal delivery.

Esterification process

Esters are formed by reacting an amino carboxylic acid with an alkylating agent in an aprotic solvent.