587832-08-4

Basic information

• Product Name: Butanoic acid, 2-hydroxy-2-methyl-, phenylmethyl ester, (2S)-
• CAS NO: 587832-08-4
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol File: 587832-08-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-hydroxy-2-methyl-, phenylmethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-hydroxy-2-methyl-, phenylmethyl ester, (2S)-(587832-08-4)
• EPA Substance Registry System: Butanoic acid, 2-hydroxy-2-methyl-, phenylmethyl ester, (2S)-(587832-08-4)

Safety Data

• Hazardous Substances Data: 587832-08-4(Hazardous Substances Data)

Upstream product

• 37505-07-0 (S)-2-hydroxy-2-methylbutyric acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 37526-88-8 benzyl tiglate 
• 1213228-96-6 C₁₉H₁₉NO₆ 
• 1092559-79-9 benzyl (R)-2-azido-2-methylbutanoate 

Relevant articles and documents

Mitsunobu approach to the synthesis of optically active α,α-disubstituted amino acids

Chiral tertiary α-hydroxy esters of known stereochemical configuration were transformed to α-azido esters by Mitsunobu reaction with HN3. Optimization of this reaction was shown to proceed at room temperature with high chemical yield using 1,1-(azodicarbonyl)dipiperidine (ADDP) and trimethylphosphine (PMe3). Complete inversion of configuration was observed at the α-carbon. Several α,α- disubstituted amino acids were synthesized in high overall chemical yield and optical purity.