587870-31-3

Basic information

• Product Name: [1,4]Dioxino[2,3-g]quinazoline-7-methanol, 4-[(3-bromophenyl)amino]-7,8-dihydro-
• CAS NO: 587870-31-3
• Molecular Formula: C17H14BrN3O3
• Molecular Weight: 388.22
• Mol File: 587870-31-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1,4]Dioxino[2,3-g]quinazoline-7-methanol, 4-[(3-bromophenyl)amino]-7,8-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,4]Dioxino[2,3-g]quinazoline-7-methanol, 4-[(3-bromophenyl)amino]-7,8-dihydro-(587870-31-3)
• EPA Substance Registry System: [1,4]Dioxino[2,3-g]quinazoline-7-methanol, 4-[(3-bromophenyl)amino]-7,8-dihydro-(587870-31-3)

Safety Data

• Hazardous Substances Data: 587870-31-3(Hazardous Substances Data)

Upstream product

• 489453-42-1 3-methoxymethyl-7-nitro-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid 
• 489453-43-2 7-amino-3-methoxymethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid 
• 489453-45-4 4-chloro-7-(methoxymethyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazoline 
• 587870-30-2 7-methoxymethyl-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-ol 
• 489453-41-0 3-methoxymethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid 
• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 
• 225927-73-1 7-acetyl-2-methoxymethyl-2,3-dihydro-benzo[1,4]dioxine 
• 20094-51-3 2-methoxymethyl-2,3-dihydro-benzo[1,4]dioxine 
• 489453-49-8 (3-bromo-phenyl)-(7-methoxymethyl-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-yl)-amine 

Downstream Products

• 489453-61-4 {4-[(3'-bromophenyl)amino]-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-7-yl}methyl methanesulfonate 

Relevant articles and documents

7-Substituted-[1,4]dioxano[2,3-g]quinazolines as inhibitors of epidermal growth factor receptor kinase

With the aim of developing inhibitors of EGFR tyrosine kinase, the 7-methoxymethyl-[1,4]dioxano[2,3-g]quinazolines (3a-b) and 7-mono- or di-alkylaminomethyl-[1,4]dioxano[2,3-g]quinazolines (4a-i) were prepared and evaluated for the inhibition of EGFR tyrosine kinase and the growth inhibition of human tumor cell lines. Among them, compounds 4d and 4h showed potencies against both EGFR tyrosine and the A431 cell line similar to that of PD153035 with greater aqueous solubilities of their HCI salts.